The drug Azaran should be used intramuscularly or intravenously struino or drip!
Standard dosing.
Adults and children over 12 years of age: the usual dose is 1-2 grams per day (every 24 hours). In severe cases, the maximum daily intake for adults is 4 g.
Newborns under the age of 14 days - 20-50 mg / kg of body weight once a day. The maximum daily dose should not exceed 50 mg / kg of body weight.
When determining the dose, no distinction is made between full and premature children.
Children aged 15 days to 12 years - 20-80 mg / kg body weight once a day.
Children with a body weight above 50 kg are prescribed doses for adults.
Intravenous doses equal to or greater than 50 mg / kg body weight should be administered as infusions for at least 30 minutes.
The duration of the course usually does not exceed 10 days. The introduction of the drug is recommended to continue for another 2-3 days after the normalization of body temperature and the disappearance of symptoms.
Dosing in special cases.
For the prevention of postoperative complications - once, 1-2 g (depending on the degree of infectious risk) for 30-90 minutes before the operation. In operations on the colon and rectum, additional administration (but separate) of the drug from the 5-nitroimidazoles group is recommended.
In acute, uncomplicated gonorrhea - IM once, 250 mg.
Borreliosis Lyme - 50 mg / kg of body weight (the highest daily dose is 2 g) for adults and children, once a day for 14 days.
In bacterial meningitis in infants and young children - 100 mg / kg body weight (but not more than 4 g) 1 time per day. The duration of treatment depends on the pathogen and can range from 4 days for Neisseria meningitidis up to 10-14 days for sensitive strains Enterobacteriaceae.
Patients with impaired renal function there is no need to reduce the dose, if the function liver remains normal. The daily dose of Azaran should not exceed 2 g, only in cases of preterminal renal failure (creatinine clearance less than 10 ml / min).
In patients with impaired liver function there is no need to reduce the dose, if the function kidneys remains normal.
When combined with severe renal and hepatic insufficiency should regularly determine the concentration of ceftriaxone in the plasma and, if necessary, adjust its dose.
Patients on dialysis additional introduction of the drug after dialysis is not required, because ceftriaxone not removed during hemodialysis. However, the concentration of ceftriaxone in the serum should be monitored for possible dose adjustment, since the rate of excretion in these patients may be reduced.
Rules for the preparation and administration of solutions: use only freshly prepared solutions!
Preparation of solution for intramuscular injection:
- 1000 mg of the drug are dissolved in 3.6 ml of water for injection, 1 ml of the resulting solution contains about 250 mg in terms of ceftriaxone. If necessary, a more dilute solution can be used.
- 1000 mg of the drug are dissolved in 3.5 ml of a 1% solution of lidocaine.
The resulting solution is injected deep into a relatively large muscle (buttock or thigh muscle). Do not administer more than 1000 mg of the drug in one muscle.
Solutions containing lidocaine can not be administered intravenously!
Preparation of solution for intravenous administration:
1000 mg of the drug are dissolved in 9.6 ml of water for injection, 1 ml of the resulting solution contains about 100 mg in terms of ceftriaxone. The solution is injected slowly for 2-4 minutes.
Preparation of a solution for intravenous infusion:
2 g of the drug is dissolved in 40 ml of water for injection or one of the infusion solutions that do not contain calcium (0.9% sodium chloride solution, 0.45% sodium chloride solution + 2.5% dextrose solution, 5% or 10% % dextrose solution, 6% dextran solution in 5% dextrose solution, 6-10% solution of hydroxyethylated starch). The duration of the infusion should be at least 30 minutes.
The prepared solution should be stored in a dark place at room temperature (25 ° C) and
use for 6 hours or in a dark place at temperature from 2 to 8 ° C and
use within 24 hours.