The drug is administered intramuscularly or intravenously (either struino or drip). Adults and children over the age of 12 years appoint 1-2 g once a day. The maximum daily dose is not more than 4.0 g.
Newborns under the age of 14 days appoint 20-50 mg / kg / day. The maximum daily dose of 50 mg / kg.
Infant and young children (from 15 days to 12 years) appoint 20-80 mg / kg / body weight once a day.
Children with body weight > 50 kg appoint doses intended for adults.
Doses of 50 mg / kg or more for intravenous administration should be administered drip for at least 30 minutes.
Patients of senile age should be administered usual doses intended for adults, without adjusting for age.
The duration of the course is usually 4-14 days; with complicated infections, a longer duration of administration may be required. The drug should be continued for 2-3 days after the disappearance of symptoms and signs of infection.
When bacterial meningitis in infants and young children, the dose is 100 mg / kg 1 time / day. The maximum daily dose is 4.0 g.
The duration of therapy depends on the type of pathogen and can range from 4 days with meningitis caused by Neisseria meningitidis, up to 10-14 days with meningitis caused by sensitive strains Enterobacteriaceae.
When Lyme disease: adults and children over 12 years of age are prescribed 50 mg / kg once a day, the maximum daily dose is 2.0 g. The duration of treatment is 14 days.
When acute uncomplicated gonorrhea the drug is administered in / m once in a dose of 250 mg.
With the aim of prevention of postoperative complications - once 1.0 g for 30-60 minutes before the operation.
When operations on the colon and rectum - effectively simultaneous (but separate) administration of Ceftriaxone and one of the 5-nitroimidazoles group.
In patients with impaired renal function, there is no need for dose adjustment if the liver function remains normal. In cases of preterminal renal failure of a severe degree with KK less than 10 ml / min, the daily dose of the drug should not exceed 2.0 g.
In patients with impaired liver function, there is no need for dose adjustment if the kidney function remains normal.
When combined with severe renal and hepatic insufficiency, the concentration of ceftriaxone in the plasma should be monitored regularly and, if necessary, its dose should be adjusted.
Patients who are on hemodialysis, additional administration of the drug after dialysis is not required. The rate of excretion of ceftriaxone in such patients may be reduced, so the concentration of the drug in the blood plasma should be monitored in order to timely dose correction.
Rules for the preparation and administration of solutions
Use only freshly prepared solutions.
For intramuscular injection 0.25 g or 0.5 g of the drug are dissolved in 2 ml and 1.0 g in 3.5 ml of water for injection. To reduce pain with I / m injections, the drug should be administered with a 1% solution of lidocaine.Enter deep into the gluteus muscle or into the muscle of the thigh. Do not administer more than 1.0 g per muscle. Lidocaine chloride solution can not be administered iv.
For intravenous administration 0.25 g or 0.5 g is dissolved in 5 ml, and 1.0 g of the preparation in 10 ml of water for injection. The solution is injected for 2-4 minutes.
For intravenous infusion 2.0 g of the drug is dissolved in 40 ml of water for injection or one of the solutions that do not contain calcium (0.9% sodium chloride solution, 0.45% sodium chloride solution + 2.5% dextrose solution, 5% solution dextrose, 10% dextrose solution, 6% dextran solution in 5% dextrose solution, 6-10% solution of hydroxyethylated starch). The solution is introduced for 30 minutes.