The drug is administered intramuscularly or intravenously.
Standard dosing regimen:
Adults and children over 12 years of age: 1-2 g once a day (every 24 hours) or 0.5-1 g every 12 hours. In severe cases or infections, the causative agents of which have only moderate sensitivity to ceftriaxone, the daily dose can be increased to 4 g.
Lyme disease (borreliosis): 50 mg / kg (the highest daily dose is 2 g) for adults and children over 12 years of age once a day for 14 days.
Uncomplicated gonorrhea (caused by penicillin-forming and penicillin-anesthetic strains): single intramuscular injection of 250 mg of the drug.
Prevention of postoperative infections, depending on the degree of infectious risk, 1-2 g of ceftriaxone is administered once 30-90 minutes before the start of the operation. In operations on the colon and rectum, simultaneous (but separate) administration of ceftriaxone and a drug from the group of 5-nitroimidazoles, for example, ornidazole, was well established.
Newborns (up to 2 weeks): 20-50 mg / kg body weight once a day. The daily dose should not exceed 50 mg / kg of body weight. When determining the dose, there is no need to distinguish between full and premature babies.
Infants and young children (from 15 days to 12 years): for the treatment of skin and soft tissue infections, the recommended daily dose is 50-75 mg / kg, divided into 2 doses (every 12 hours). The total daily dose in children should not exceed 2 g. For bacterial meningitis in children, the initial dose is 100 mg / kg (but not more than 4 g) once a day, then 100 mg / kg / day (but not more than 4 g) 1 time per day or divided into 2 doses (every 12 hours). The duration of treatment is 7-14 days.
In the treatment of acute otitis media in children, a single IV IM is recommended in a dose of 50 mg / kg (but not more than 1 g).
In the treatment of other infections in children, the recommended daily dose is 50-75 mg / kg, divided into 2 divided doses (every 12 hours). The total daily intake for children should not exceed 2 g.
In children with a body weight of 50 kg and above, doses for adults are used.
A dose of more than 50 mg / kg of body weight should be given as an IV infusion for 30 minutes.
Elderly patients: usual doses for adults, without adjustments for age.
In patients with impaired renal function There is no need to reduce the dose if the liver function remains normal. The daily dose of ceftriaxone should not exceed 2 g only in cases of renal insufficiency with creatinine clearance less than 10 ml / min.
In patients with hepatic dysfunction there is no need to reduce the dose if the kidney function remains normal.
When combination of severe renal and hepatic insufficiency should regularly determine the concentration of ceftriaxone in the plasma and, if necessary, adjust its dose. The daily dose should not exceed 2 g without determining the concentration of the drug in the blood plasma.
Patients on hemodialysis do not require an additional dose after a hemodialysis session, however, it is necessary to control the concentration of ceftriaxone in the plasma, since its excretion in such patients can be slowed down (dose adjustment may be required).
Treatment with ceftriaxone should continue for at least 2 more days after the disappearance of symptoms and signs of infection. The course of treatment is usually 4-14 days; with complicated infections, a longer duration of administration may be required. The course of treatment for infections caused by Streptococcus pyogenes, must be at least 10 days.
Rules for the preparation and administration of solutions: use only freshly prepared solutions.
For intramuscular injection: the contents of the vial (1 g) are dissolved in 3.6 ml of water for injection. After preparation, each ml of the solution contains about 250 mg in terms of ceftriaxone.
If necessary, a more dilute solution may be used. As with other intramuscular injections, the Axon drug is injected into a relatively large muscle; Trial aspiration helps to avoid unintentional insertion into the blood vessel. It is recommended to inject not a bolt of 1000 mg of the drug into one relatively large muscle. To reduce pain with intramuscular injections, the drug should be administered with a 1% solution of lidocaine. Do not inject lidocaine solution intravenously.
For intravenous administration: the contents of the vial (1 g) are dissolved in 9.6 ml of water for injection. After preparation, each ml of the solution contains about 100 mg in terms of ceftriaxone. The solution is administered slowly for 2-4 minutes.
For intravenous infusion dissolved 2 g in 40 ml of sterile water for injection or one of infusion solutions not containing calcium (0.9% sodium chloride, 2.5%, 5% or 10% dextrose solution, 5% levulose solution, 6% dextran solution in dextrose) . The solution is introduced for 30 minutes.