Intravenous, intramuscular. Do not use Ca2 + -containing solutions to dilute the preparation!
In adults, the initial daily dose, depending on the type and severity of the infection, is 1 to 2 g once a day or divided into 2 divided doses (every 12 hours), the total daily dose should not exceed 4 g.
Lyme disease: adults and children - 50 mg / kg (but not more than 2 g) 1 time per day for 14 days. With uncomplicated gonorrhea - 250 mg IM once.
For the prevention of postoperative complications - once 1 g for 30 - 60 minutes before the operation.
In operations on the colon and rectum, an additional injection of the drug from the group 5-nitroimidazoles is recommended. The dose for newborns is 20 - 50 mg / kg / day.
For the treatment of infections of the skin and soft tissues, the recommended daily intake in children is 50 to 75 mg / kg, divided into 2 divided doses (every 12 hours). The total daily intake for children should not exceed 2 g.
For bacterial meningitis in children, the initial dose is -100 mg / kg (but not more than 4 g) once a day, then 100 mg / kg / day (but not more than 4 g) once a day or divided into 2 doses (every 12 hours). Duration of treatment - 7 - 14 days.
In the treatment of acute otitis media in children, a single IV IM is recommended in a dose of 50 mg / kg (but not more than 1 g).
In the treatment of other infections in children, the recommended daily intake in children is 50 to 75 mg / kg, divided into 2 divided doses (every 12 hours).The total daily intake for children should not exceed 2 g.
In children with a body weight of 50 kg and above, doses for adults are used.
A dose of more than 50 mg / kg body weight should be given as an IV infusion for 30 minutes.
In chronic renal failure (CRF) (CK less than 10 ml / min) - the daily dose should not exceed 2 g; patients on hemodialysis do not require an additional dose after a hemodialysis session, however, it is necessary to control the concentration of ceftriaxone in the plasma, since its excretion in such patients can be slowed down (dose adjustment may be required).
In patients with renal-hepatic insufficiency, the daily dose should not exceed 2 g without determining the concentration of ceftriaxone in the blood plasma. Treatment with ceftriaxone should continue for at least 2 more days after the disappearance of symptoms and signs of infection. The course of treatment is usually 4-14 days; with complicated infections, a longer duration of administration may be required. The course of treatment for infections caused by Streptococcus pyogenes should be at least 10 days.
Rules for the preparation and administration of solutions: Use only freshly prepared solutions.For the / m introduction, 0.25 or 0.5 g of the drug is dissolved in 2 ml, and 1 g in 3.5 ml of a 1% solution of lidocaine. Recommend to enter no more than 1 g in one buttock.
For intravenous injection, 0.25 or 0.5 g is dissolved in 5 ml, and 1 g in 10 ml of water for injection. Enter into / in slowly (2-4 minutes).
For intravenous infusions, dissolve 2 g in 40 ml of a solution that does not contain Ca2 + (0.9% sodium chloride solution (NaCl), 5-10% dextrose solution, 5% fructose solution). Doses of 50 mg / kg or more should be administered intravenously in drip, for 30 minutes.