The drug is used intramuscularly and intravenously (drip and jet).
For adults and for children over 12 years old
The average daily dose is 1-2 g of ceftriaxone once a day or 0.5-1 g every 12 hours. In severe cases or in cases of infections caused by moderately sensitive pathogens, the daily dose can be increased to 4 g.
For newborns (up to 4 weeks)
For a single daily dosage, the following regimen is recommended: for newborns (up to 2 weeks of age): 20-50 mg / kg of body weight per day (a dose of 50 mg / kg of body weight is not recommended because of immature neonatal enzyme system).In determining the dose, a distinction should not be made between full-term and preterm neonates.
For infants (from 4 weeks) and children under 12 years
The daily dose is 20-80 mg / kg body weight, with: a single injection. Children with a body weight of 50 kg and above should adhere to the dosage for adults. A dose of more than 50 mg / kg body weight should be given as an intravenous infusion, for at least 30 minutes.
Duration of therapy set individually. As a rule, the administration of the drug should be continued for another 48-72 hours after the temperature is normalized and the eradication of the pathogen is confirmed.
Meningitis
In bacterial meningitis in infants and young children, the initial dose is 100 mg / kg of body weight once a day (maximum 4 g). Once it was possible to isolate the pathogenic microorganism and determine its sensitivity, the dose should be reduced accordingly. The best results were achieved with the following periods of therapy:
| Causative agent | Duration of therapy |
| Neisseria meningitidis | 4 days |
| Haemophilus influenzae | 6 days |
| Streptococcus pneumoniae | 7 days |
| Sensitive Enterobacteriacea | 10-14 days |
Gonorrhea
For the treatment of gonorrhea: 250 mg once intramuscularly.
Borreliosis Lyme
50 mg / kg (the highest daily dose is 2 g) for adults and children over 12 years of age once a day for 14 days.
Prevention of postoperative infections
Depending on the degree of infectious risk, 1-2 g of ceftriaxone is administered once 30-90 minutes before the operation. In operations on the colon and rectum, simultaneous (but separate) administration of ceftriaxone and one of 5-nitroimidazoles has proved to be well established.
Lack of kidney and liver function
In patients with impaired renal function, under the condition of normal liver function, a dose of ceftriaxone is not necessary to reduce. Correction of the dose is required only at creatinine clearance values below 10 ml / min. In this case, the daily dose of ceftriaxone should not exceed 2 g.
In patients with impaired liver function, if the function of the kidneys is maintained, the dose of ceftriaxone should not be reduced.
In cases of a combination of severe heathology of the liver and kidneys, the concentration of ceftriaxone in serum should be monitored regularly and, if necessary, adjusted its dosage.
Patients on dialysis additional introduction of the drug after dialysis is not required.It should, however, control the concentration of ceftriaxone in the serum for possible dose adjustment, since the rate of excretion of the drug in these patients may be reduced.
Intramuscular injection
For intramuscular administration, 1 g of the drug should be diluted in 3.5 ml of a 1% solution of lidocaine and inserted deep into the gluteal muscle, trial aspiration helps to avoid unintentional insertion into the blood vessel. It is recommended to inject no more than 1 g of the drug into one buttock. A solution of ceftriaxone diluted with lidocaine can not be administered intravenously, but only intramuscularly.
Intravenous administration
For intravenous injection, 1 g of the drug must be diluted in 10 ml of sterile distilled water and administered intravenously slowly for 2-4 minutes.
Intravenous infusion
For intravenous infusion of 2 g of the powder should be diluted with approximately 40 ml of a solution free of calcium, such as 0.9% sodium chloride solution, 5% dextrose solution, 10% dextrose solution, 5% fructose solution. Duration of intravenous infusion is at least 30 minutes.