Adults and children over 12 years of age: 1-2 g once a day (every 24 hours): In severe cases or infections, the causative agents of which have only moderate sensitivity to ceftriaxone, the daily dose can be increased to 4 g.
Lyme disease (borreliosis): 50 mg / kg (the highest daily dose is 2 g) for adults and children over 12 years old once a day for 14 days.
Uncomplicated gonorrhea: 250 mg IM once.
Prevention of postoperative infections: depending on the degree of infectious risk, 1-2 g of the drug is administered once for 30-90 min before the operation. In operations on the colon and rectum, simultaneous (but separate) administration of the drug and one of 5-nitroimidazoles, for example, ornidazole, was well established.
Newborns (up to 2 weeks): 20-50 mg / kg body weight once a day. The daily dose should not exceed 50 mg / kg of body weight. When determining the dose, there is no need to distinguish between full and premature children;
Infant and young children (from 15 days to 12 years): 20-80 mg / kg body weight once a day (or divided into two applications). The total daily intake for children should not exceed 2 g.
For the treatment of skin and soft tissue infections, the recommended daily intake in children is 50-75 mg / kg divided into 2 divided doses (every 12 hours). The total daily dose in children should not exceed 2 in
With bacterial meningitis the children lTreatment starts at a dose of 100 mg / kg (but not more than 4 g) once a day, then 100 mg / kg / day (but not more than 4 g) once a day or divided into 2 divided doses (every 12 hours).Duration of treatment is 7-14 days.
Children with a body weight of 50 kg and above appoint doses for adults. An IV dose of 50 mg / kg or higher should be administered drip for at least 30 minutes.
To the elderly: the usual doses provided for adults, without adjusting for age.
In patients with impaired renal function There is no need to reduce the dose if the liver function remains normal. The daily dose of ceftriaxone should not exceed 2 g only in cases of renal insufficiency with creatinine clearance less than 10 ml / min. In patients with impaired liver function, there is no need to reduce the dose if the kidney function remains normal.
When combined with severe renal and hepatic insufficiency should regularly determine the concentration of ceftriaxone in the plasma and, if necessary, adjust the dose of the drug. The daily dose should not exceed 2 g without determining the concentration of ceftriaxone in the blood plasma.
Patients undergoing hemodialysis additional introduction of the drug after dialysis is not required. It should, however, monitor the concentration of ceftriaxone in the plasma, since the rate of excretion in these patients may decrease (dose adjustment may be required). The duration of treatment depends on the nature and severity of the disease.Treatment with the drug should continue for at least 2 days after the disappearance of symptoms and signs of infection. The course of treatment is usually 4-14 days; with complicated infections, a longer duration of administration may be required. The course of treatment for infections caused by Streptococcus pyogenes, must be at least 10 days.
Rules for the preparation and administration of solutions:
Use only freshly prepared solutions.
For an intravenous injection, 500 mg of the drug is dissolved in 2 ml, 1.0 g in 3.6 ml of water for injection and injected deeply into the gluteus muscle. After preparation, each ml of the solution contains about 250 mg in terms of ceftriaxone. It is recommended to inject no more than 1.0 g in one buttock. To reduce pain as a solvent, 1% lidocaine solution can be used. The solution containing lidocaine, can not be administered intravenously!
For IV injection 500 mg of the drug in 4.8 ml is dissolved, and 1.0 g is dissolved in 9.6 ml of water for injection. After preparation, each ml of the solution contains about 100 mg in terms of ceftriaxone. The solution is injected iv slowly for 2-4 minutes.
The IV infusion should last at least 30 minutes. To prepare the solution, dilute 2.0 g of the drug in 40 ml of water for injection or one of the following infusion solutions,not containing calcium ions: 0.9% solution of sodium chloride, 5%, 10% dextrose solution, 5% solution of fructose.
Ceftriaxone solutions should not be mixed or added to solutions containing others. antibiotics or other solvents, with the exception of those listed above, because of the possible incompatibility.