For adults and for children over 12 years of age:
The average daily dose is 1-2 g of ceftriaxone 1 time per day (after 24 hours). In severe cases or in cases of infections caused by moderately sensitive pathogens, a one-time daily dose may be increased to 4 g.
For newborns, infants and children under 12 years of age: For a single daily dosage, the following scheme is recommended.
For newborns (up to 2 weeks of age): 20-50 mg / kg of body weight per day (a dose of 50 mg / kg of body weight is not allowed to exceed in connection with the immature enzyme system of newborns).
For infants and children under 12 years of age: The daily dose is 20-75 mg / kg body weight. In children with a body weight of 50 kg and above, the dosage for adults should be followed. A dose of more than 50 mg / kg body weight should be given as an intravenous infusion for at least 30 minutes.
Duration of therapy: depends on the course of the disease.
Combination therapy:
In the experiments it was proved that synergism takes place between ceftriaxone and aminoglycosides on the effect on many Gram-negative bacteria. Although it is impossible to predict the potentiated effect of such combinations in advance, in cases of severe and life-threatening infections (for example, Pseudomonas aeruginosa) their joint appointment is justified.
In connection with the physical incompatibility of ceftriaxone and aminoglycosides,
appoint them in recommended doses separately!
Meningitis:
In bacterial meningitis in newborns and in children, the initial dose is 100 mg / kg of body weight once a day (maximum 4 g). Once it was possible to isolate the pathogenic microorganism and determine its sensitivity, the dose should be reduced accordingly.
The best results were achieved with the following periods of therapy:
| Causative agent | Duration of therapy | |
| Neisseria meningitidis | 4 days | |
| Haemophilus influenza | 6 days |
| Streptococcus pneumoniae | 7 days |
| Sensitive Enterobacteriacease | 10-14 days |
Gonorrhea:
For the treatment of gonorrhea caused by both generative and non-penicillinase-resistant strains, the recommended dose is 250 mg once intramuscularly.
Prevention in the pre- and postoperative period:
Before infected or suspected infected surgical interventions to prevent postoperative infections, depending on the risk of infection, one-time administration of ceftriaxone in a dose of 1-2 g is recommended 30-90 minutes prior to surgery.
Lack of kidney and liver function: In patients with impaired renal function, under the condition of normal liver function, a dose of ceftriaxone is not necessary to reduce. Only if the kidney function in the preterminal stage is insufficient (creatinine clearance below 10 ml / min), that the daily dose of ceftriaxone does not exceed 2 g. In patients with impaired hepatic function, if the function of the kidneys is maintained, the dose of ceftriaxone should not be reduced.
In cases of simultaneous presence of severe pathology of the liver and kidneys, the concentration of ceftriaxone in serum should be monitored regularly. In patients undergoing hemodialysis, the dose of the drug after this procedure is not necessary to change. Intramuscular administration:
For intramuscular administration, 1 g of the drug should be diluted in 3.5 ml of a 1% solution of lidocaine and inserted deep into the gluteal muscle,it is recommended to inject no more than 1 g of the drug into one buttock. A solution of lidocaine can never be administered intravenously!
Intravenous administration:
For intravenous injection, 1 g of the drug should be diluted in 10 ml of sterile distilled water and administered intravenously slowly for 2-4 minutes.
Intravenous infusion:
The duration of the intravenous infusion is at least 30 minutes.
For intravenous infusion, 2 g of powder should be diluted in approximately 40 ml of calcium free solution, for example: 0.9% solution of sodium chloride, 5% glucose solution, 10% glucose solution, 5% levulose solution.