The drug is used intramuscularly and intravenously.
For adults and for children over 12 years old
The average daily dose is 1-2 g of ceftriaxone 1 time per day (after 24 hours).
In severe cases or in cases of infections caused by moderately sensitive pathogens, a single daily dose may be increased to 4 g.
For newborns, infants and children under 12 years of age
For a single daily dosage, the following scheme is recommended:
For newborns (up to 2 weeks of age): 20-50 mg / kg of body weight per day (a dose of 50 mg / kg of body weight is not recommended because of the immature enzyme system of newborns).
For infants and children under 12 years of age
The daily dose is 20-75 mg / kg body weight.
Children with a body weight of 50 kg and above should adhere to the dosage for adults. A dose of more than 50 mg / kg body weight should be given as an intravenous infusion, for at least 30 minutes.
Duration of therapy
Depends on the course of the disease.
Meningitis
In bacterial meningitis in newborns and in children, the initial dose is 100 mg / kg of body weight once a day (maximum 4 g). Once it was possible to isolate the pathogenic microorganism and
determine its sensitivity to the dose must be reduced accordingly. The best results were achieved with the following periods of therapy:
| Causative agent | Duration of therapy |
| Neisseria meningitidis | 4 days |
| Haemophilus influenzae | 6 days |
| Streptococcus pneumoniae | 7 days |
| Sensitive Enterobacteriacease | 10 - 14 days |
Gonorrhea
For the treatment of gonorrhea caused by both generative and non-penicillinase-resistant strains, the recommended dose is 250 mg once intramuscularly.
Prevention in the pre- and postoperative period
Before infected or suspected infected surgical interventions to prevent postoperative infections, depending on the risk of infection, one-time administration of ceftriaxone in a dose of 1-2 g is recommended 30-90 minutes prior to surgery.
Lack of kidney and liver function
In patients with impaired renal function, under the condition of normal liver function, a dose of ceftriaxone is not necessary to reduce. Only if the kidneys are deficient in the preterminal stage (creatinine clearance below 10 ml / min) it is necessary that the daily dose of ceftriaxone does not exceed 2 g.
In patients with impaired liver function, if the function of the kidneys is maintained, the dose of ceftriaxone should not be reduced.
In cases of simultaneous presence of severe pathology of the liver and kidneys, the concentration of ceftriaxone in serum should be monitored regularly. In patients undergoing hemodialysis, the dose of the drug after this procedure is not necessary to change.
Intramuscular injection
For intramuscular injection, 1 g of the drug should be diluted in 3.5 ml of a 1% solution of lidocaine and inserted deep into the gluteal muscle, it is recommended to inject no more than 1 g of the drug into one buttock. A solution of lidocaine can never be administered intravenously!
Intravenous administration
For intravenous injection, 1 g of the drug should be diluted in 10 ml of sterile distilled water and administered intravenously slowly for 2-4 minutes.
Intravenous infusion
Duration of intravenous infusion is at least 30 minutes. For intravenous infusion of 2 g of the powder should be diluted with approximately 40 ml of a solution free of calcium, such as 0.9% sodium chloride solution, 5% dextrose solution, 10% dextrose solution, 5% fructose solution.