The incidence of side effects is indicated according to the following definitions: very often more than 1/10, often more than 1/100 and less than 1/10, infrequently more than 1/1000 and less than 1/100, rarely more than 1/10000 and less than 1 / 1000, very rarely - less than 1/10000, including isolated cases.
From the hematopoiesis: rarely - eosinophilia, leukopenia, granulocytopenia; very rarely, including isolated cases - thrombocytosis, thrombocytopenia, a slight increase in prothrombin time, individual cases of agranulocytosis (<500 cells / μl),most of them developed after 10 days of treatment and a cumulative dose of 20 g or more, anemia (including hemolytic), neutropenia, lymphopenia.
From the digestive system: infrequently - stomatitis, glossitis, nausea, vomiting, abdominal pain, diarrhea or constipation, very rarely - a taste disorder, pseudomembranous colitis.
From the nervous system: infrequently - headache, dizziness.
From the genitourinary system: infrequently - oliguria, candidiasis of the vagina, vaginitis; rarely - the formation of calculi in the kidneys, mainly in children older than 3 years, who received either large daily doses of the drug (> 80 mg / kg / day), or cumulative doses of more than 10 g, as well as those who had additional risk factors (restriction of fluid intake, bed rest, etc.). The formation of calculi in the kidneys can be asymptomatic or manifest clinically, can lead to kidney failure and reversibly after discontinuation of therapy with the drug.
Local Reactions: often - with intravenous injection - phlebitis, soreness, tightening along the vein (phlebitis can be avoided by injecting the drug slowly for 2-4 minutes); when administered intramuscularly, tenderness, sensation of heat, tightness, or compaction at the site of administration.
Allergic reactions: often - hives, rash, itching; infrequently - chills or fever. Laboratory indicators: often - increased urea concentration, increased activity of "liver" transaminases; rarely - increased activity of alkaline phosphatase (AF), hyperbilirubinemia, hypercreatininaemia, the presence of sediment in the urine.
Other: rarely - increased sweating, blood flushes, allergic pneumonitis, basophilia, cholelithiasis, bronchospasm, colitis, dyspepsia, epistaxis, pancreatitis, bloating, "sluggish phenomenon" of the gallbladder, glucosuria, hematuria, jaundice, leukocytosis, lymphocytosis, monocytosis, palpitations, convulsions, serum sickness, allergic dermatitis, edema, erythema multiforme, Stevens-Johnson syndrome, Lyell syndrome, anaphylactic or anaphylactoid reactions.