The drug is administered intramuscularly or intravenously.
Standard dosing regimen
For adults and for children over 12 years of age:
The average daily dose is 1-2 g of ceftriaxone once a day (every 24 hours).
In severe cases or in cases of infections caused by moderately sensitive pathogens, a one-time daily dose may be increased to 4 g.
For newborns (up to 2 weeks of age): 20-50 mg / kg of body weight once a day (a dose of 50 mg / kg of body weight is not allowed to exceed in connection with the immature enzyme system of newborns).When determining the dose, there is no need to distinguish between full and premature babies. For infants and children under 12 years (from 15 days to 12 years): The daily dose is 20-80 mg / kg body weight.
Children with a body weight of 50 kg and above should be given doses for adults. The drug at a dose of 50 mg / kg body weight and more should be administered as an intravenous infusion for at least 30 minutes.
Patients of senile age: usual doses for adults, without adjustments for age.
Duration of treatment depends on the course of the disease. As always with antibiotic therapy, ceftriaxone should be continued for at least 48-72 hours after the temperature is normalized and the eradication of the pathogen is confirmed.
Dosing in special cases:
Meningitis:
In bacterial meningitis in infants and young children, the initial dose is 100 mg / kg body weight once a day (maximum 4 g). As soon as it was possible to isolate the pathogenic microorganism and determine its sensitivity, the dose should be reduced accordingly. The best
| Causative agent | Duration of therapy |
| Neisseria meningitidis | 4 days |
| Haemophilus influenzae | 6 days |
| Streptococcus pneumoniae | 7 days |
| Sensitive Enterobacteriaceae | 10-14 days |
Borrelia Lyme: 50 mg / kg (the highest daily dose is 2 g) for adults and children over 12 years of age once a day for 14 days.
Gonorrhea: For the treatment of gonorrhea, caused by both generative and non-penicillinase-producing strains, the recommended dose is 250 mg once intramuscularly.
Prevention of postoperative infections, depending on the degree of infectious risk, 1-2 g of ceftriaxone is administered once 30-90 minutes before the start of the operation. In operations on the colon and rectum, simultaneous (but separate) administration of ceftriaxone and one of 5-nitroimidazoles has proved to be well established.
Lack of kidney and liver function:
In patients with impaired function of the kidneys, with normal liver function, there is no need to reduce the dose of ceftriaxone. Only if the kidneys are deficient in the preterminal stage (creatinine clearance below 10 ml / min), it is necessary that the daily dose of ceftriaxone does not exceed 2 g. In patients with impaired function of the liver, provided that the function of the kidneys is preserved, a dose of ceftriaxone is also not necessary to reduce.
When combination of severe renal and hepatic insufficiency should regularly determine the concentration of ceftriaxone in the plasma and, if necessary, adjust its dose.
Patients on dialysis additional introduction of the drug after dialysis is not required. It should, however, control the concentration of ceftriaxone in the serum for possible dose adjustment, since the rate of excretion of the drug in these patients may be reduced.
Mode of application
For intramuscular injection:
The contents of the vial are dissolved as follows:
Contents of the bottle Solvent (water for injection)
1.0 g 3.5 ml
After preparation, each ml of the solution contains about 250 mg in terms of ceftriaxone.
If necessary, a more dilute solution may be used. As with other intramuscular injections ceftriaxone injected into a relatively large muscle (gluteal); Trial aspiration helps to avoid unintentional insertion into the blood vessel. It is recommended to inject no more than 1000 mg of the drug into one muscle. To reduce pain with intramuscular injections, the drug should be administered with a 1% solution of lidocaine. Do not inject lidocaine solution intravenously.
For intravenous administration:
The contents of the vial are dissolved as follows:
Contents of the bottle Solvent (water for injections)
1.0 g 10.0 ml
After preparation, each ml of the solution contains about 100 mg in terms of ceftriaxone. The solution is administered slowly for 2-4 minutes.
For intravenous infusion dissolve 2 g of ceftriaxone in 40 ml of sterile water for injection or one of the infusion solutions that do not contain calcium (0.9% sodium chloride solution, 2.5%, 5% or 10% dextrose solution, 5% levulose solution, 6% dextran solution in dextrose) . The solution is introduced for 30 minutes.