For adults and children over 12 years of age, the initial daily dose, depending on the type and severity of the infection, is 1-2 grams once a day or divided into 2 divided doses (every 12 hours), the total daily dose should not exceed 4 g.
Lyme disease: adults and children - 50 mg / kg (but not more than-2 g) 1 time per day for 14 days.
With uncomplicated gonorrhea - 250 mg IM once.
For the prevention of postoperative complications - once 1 g for 30-60 minutes before the operation. In operations on the colon and rectum, additional administration of a drug from the 5-nitroimidazole group is recommended. The dose for newborns is 20-50 mg / kg / day.
For the treatment of skin and soft tissue infections, the recommended daily intake in children is 50-75 mg / kg divided into 2 divided doses (every 12 hours). The total daily intake for children should not exceed 2 g.
For bacterial meningitis in children, the initial dose is 100 mg / kg (but not more than 4 g) once a day, then 100 mg / kg / day (but not more than 4 g) once a day or divided into 2 doses (every 12 hours). Duration of treatment is 7-14 days.
In the treatment of acute otitis media in children, a single IV IM is recommended in a dose of 50 mg / kg (but not more than 1 g).
In the treatment of other infections in children, the recommended daily dose is 50-75 mg / kg, divided into 2 doses (every 12 hours). The total daily intake for children should not exceed 2 g.
In children with a body weight of 50 kg and above, doses for adults are used.
A dose of more than 50 mg / kg of body weight should be given as an IV infusion for 30 minutes.
With CRF (CC less than 10 ml / min) - the daily dose should not exceed 2 g; patients on hemodialysis do not require an additional dose after a hemodialysis session, however, it is necessary to control the concentration of ceftriaxone in the plasma, since its excretion in such patients can be slowed down (dose adjustment may be required).
Treatment with ceftriaxone should continue for at least 2 more days after the disappearance of symptoms and signs of infection. The course of treatment is usually 4-14 days; with complicated infections, a longer duration of administration may be required.The course of treatment for infections caused by Streptococcus pyogenes should be at least 10 days.
Children with skin and soft tissue infections - in a daily dose of 50-75 mg / kg once a day or 25-37.5 mg / kg every 12 hours, not more than 2 g / day. With average otitis media, once a month, 50 mg / kg, not more than 1 g. Patients with chronic renal insufficiency correction of the dose is required only with QC below 10 ml / min. In this case, the daily dose should not exceed 2 g.
In patients with renal-hepatic insufficiency, the daily dose should not be exceed 2 g without determining the concentration of the drug in the blood plasma.
Right-hander of preparation and introduction of solutions: only freshly prepared solutions should be used. Freshly prepared solutions of the drug are stable in for 6 hours at room temperature and for 24 hours at a temperature of 2-8 ° C.
For intramuscular injection, 0.5 g of the drug is dissolved in 2 ml, and 1 g in 3 ml of 5% a solution of lidocaine or water for injection. The resulting solution can not be administered intravenously! When intramuscular introduction in one gluteal muscle is recommended to enter no more than 1 g of the drug.
For intravenous administration, the drug is dissolved in sterile water for injection in ratio of 1:10 (0.5 g in 5 ml, 1 g in 10 ml).Enter intravenously slowly (during 2-4 min). For intravenous infusion, 2 g of the drug is dissolved in 40 ml of a solution free of calcium ions (0.9% sodium chloride solution, 5 % or 10% dextrose solution, 5% solution of levulose). Doses of 50 mg / kg or more should be administered intravenously in drip, for 30 minutes.
The introduction of calcium-containing solutions or drugs is allowed no earlier than than 48 hours after the last injection / infusion of ceftriaxone.