Enter intravenously (IV) or intramuscularly (IM). For adults and for children over 12 years of age:
The average daily dose is 1000-2000 mg ceftriaxone 1 time per day (every 24 hours).
In severe cases or in cases of infections caused by moderately sensitive pathogens, a single daily dose can be increased to 4000 mg.
For infants (including newborns) and children under 12 years of age: when applied once a day, the following scheme is recommended:
for newborns - 20-50 mg / kg / day (do not exceed the dose of 50 mg / kg / day due to the immature enzyme system in newborns).
for infants and children under 12: The daily dose is 20-75 mg / kg body weight. Children with a body weight of 50 kg and above should use a dose for adults.A dose of more than 50 mg / kg body weight should be given as an intravenous infusion, for at least 30 minutes.
Duration of therapy: depends on the course of the disease. Treatment is recommended to continue for another 48 to 72 hours nocjje normalization of temperature and laboratory confirmation of eradication of the pathogen.
Combination therapy: in studies it has been proven that synergism takes place between ceftriaxone and aminoglycosides in influencing many Gram-negative bacteria. Although it is impossible to predict the potentiated effect of such combinations in advance, in the case of serious and life-threatening infections (for example, Pseudomonas aeruginosa) their joint appointment is justified. In connection with the pharmaceutical incompatibility of ceftriaxone and aminoglycosides, it is necessary to prescribe them separately in recommended doses! Dosing in special cases
Meningitis: at bacterial meningitis - in children the initial dose is 100 mg / kg of body weight once a day (max. 4000 mg). Once it was possible to isolate the pathogenic microorganism and determine its sensitivity to ceftriaxone, it is necessary to reduce the dose in accordance with the obtained data.The best results were achieved with the following periods of therapy: ________________
| Causative agent | Duration of therapy |
| Neisseria meningitidis | 4 days |
| Haemophilus influenzae | 6 days |
| Streptococcus pneumoniae | 7 days |
| Sensitive Enterobacteriaceae | 10-14 days |
Gonorrhea: for the treatment of gonorrhea caused by both generic and non-penicillinase-resistant strains, the recommended dose is 250 mg once intramuscularly.
Borrelia Lyme: 50 mg / kg (the highest daily dose is 2000 mg) for adults and children, once a day for 14 days.
Prevention in the pre- and postoperative period: for the prevention of postoperative infections, a single administration of ceftriaxone in a dose of 1000-2000 mg for 30-90 minutes before surgery is recommended. In operations on the colon and rectum, simultaneous (but separate) administration of 2000 mg of ceftriaxone and one of the antimicrobial agents, which is active against anaerobic microorganisms, is recommended.
Lack of kidney and liver function: in patients with impaired renal function, under the condition of normal liver function, a dose of ceftriaxone is not necessary to reduce. Only if the kidneys are deficient in the terminal stage (creatinine clearance below 10 ml / min), the daily dose of ceftriaxone should not exceed 2000 mg.
In patients with impaired hepatic function, if the function of the kidneys is maintained, the dose of ceftriaxone should not be reduced.
In cases of simultaneous presence of severe pathology of the liver and kidneys, the concentration of ceftriaxone in serum should be monitored regularly. Patients on hemodialysis do not need to enter an additional dose after a dialysis session. It is, however, necessary to monitor the concentration of ceftriaxone in the serum for possible dose adjustment.
Right-handed solution for intramuscular injection: for intramuscular administration 1000 mg of the drug must be diluted in 3.5 ml of a 1% solution of lidocaine and inserted deep into the gluteus muscle. It is recommended to inject no more than 1000 mg of the drug into one muscle. Trial aspiration helps to avoid unintentional entry into the vessel. The resulting solution can not be administered intravenously!
Right-hand solution for intravenous administration: for intravenous injection, 1000 mg of the drug must be diluted in 10 ml of water for injection and administered intravenously slowly for 2-4 minutes.
For intravenous infusion, 2000 mg of the powder should be diluted in approximately 40 ml of the solution,not containing calcium ions, for example, 0.45% or 0.9% sodium chloride solution, 2.5%, 5% or 10% solution of glucose, 5% fructose solution, water for injection.
The duration of intravenous infusion should be at least 30 minutes. Ceftriaxone solutions should not be mixed or added to solutions containing other antibiotics or other solvents, except for the above, because of potential incompatibility.