Choline alfoscerate - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Choline alfoscerate is a holinomimetic of central action with a predominant effect on the central nervous system. The composition of the drug includes 40.5% of choline released from the compound in the brain; Choline is involved in the biosynthesis of acetylcholine (one of the main neurotransmitter mediators). Alphoscerate is biotransformed to glycerophosphate, which is a precursor of phospholipids.

Acetylcholine positively affects the transmission of nerve impulses, and glycerophosphate is involved in the synthesis of phosphatidylcholine (membrane phospholipid), resulting in improved membrane elasticity and receptor function.

Choline alphoscerate increases cerebral blood flow, enhances metabolic processes and activates the structures of the reticular formation of the brain, and also restores consciousness in traumatic brain lesions.

Has a preventive and corrective effect on the factors of involuntary psychoorganic syndrome, such as changes in the phospholipid composition of neuronal membranes and a decrease in cholinergic activity. In this way, choline alphoscerate acts on the synaptic, including the cholinergic transmission of the nerve impulse (neurotransmission), the plasticity of the neuronal membrane, the function of the receptors. Has no effect on the reproductive cycle, does not have a teratogenic and mutagenic effect.

Pharmacokinetics:Penetrates through the blood-brain barrier (concentration in the brain - 45% of that in the plasma). Both choline and glycerophosphate ion are included in the total metabolism, therefore it is not possible to trace their real elimination from the body. However, it is known that they are metabolized to carbon dioxide, water, phosphates and nitrogen-containing products.

Indications:

- Organic mental disorders in neurodegenerative diseases and chronic impairment of cerebral circulation; primary or secondary cognitive impairments characterized by memory loss, confusion and disorientation, decreased motivation and initiative, attention impairment.

- Affective disorders in senile degeneration of the brain: emotionally labile disorder, irritability, apathy.

Contraindications:Hypersensitivity to choline alfoscerate and drugs with a similar chemical structure, hemorrhagic stroke (acute stage), pregnancy, lactation, children under 18 years.

Pregnancy and lactation:The drug is contraindicated for use during pregnancy and during breastfeeding.

Dosing and Administration:Intramuscularly (slowly) or intravenously (drip) at a dose of 1000 mg / day (1 ampoule). With intravenous administration, the contents of one ampoule (4 ml) are diluted in 50 ml of 0.9% sodium chloride solution, the infusion rate is 60-80 drops per minute. Duration of treatment is usually 10 days, but if necessary, treatment can be continued until positive dynamics appear.

Side effects:

From the digestive system: constipation, diarrhea, nausea, dryness of the oral mucosa, pharyngitis.

From the nervous system: headache, drowsiness, insomnia, aggressiveness, anxiety, nervousness, dizziness.

From the skin: a rash, hives.

Other: pain at the injection site, frequency of urination.

Overdose:

Symptoms: nausea.

Treatment: symptomatic therapy.

Interaction:No significant drug interaction of choline with other drugs was detected.

Special instructions:Nausea can be a consequence of dopaminergic activation. When this symptom appears, it is recommended to lower the dose of the drug. As a rule, the drug is well tolerated even with prolonged use.

Effect on the ability to drive transp. cf. and fur:During the period of treatment, care must be taken when driving vehicles and when engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.

Form release / dosage:Solution for intravenous and intramuscular injection 250 mg / ml.

Packaging:

4 ml in ampoules of colorless neutral glass. 10 ampoules in a box of cardboard.

3 or 5 ampoules in a contoured cell pack of polyvinyl chloride film and aluminum foil printed lacquered, or without foil. 1 or 2 contour squares in a pack of cardboard. In each pack, the box is attached instructions for use, the ampullar scarifier.

Ampoule scapper does not invest in case of using ampoules with a kink ring or with an incision and a point.

Storage conditions:In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:2 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-002522

Date of registration:04.07.2014

Date of cancellation:2019-07-04

The owner of the registration certificate:SYNTHESIS, OJSC SYNTHESIS, OJSC Russia

Manufacturer: & nbsp

SYNTHESIS, OJSC Russia

Information update date: & nbsp26.09.2015

Illustrated instructions

Instructions

Choline alfoscerate (Choline alfoscerate)