Levomycetin - instructions for use, dose, side effects, contraindications

The active substance of the drug is chloramphenicol - a broad-spectrum antibiotic with high antibacterial activity against the causative agent of wound infection and various forms of purulent-inflammatory processes. Chloramphenicol - bacteriostatic antibiotic, disrupts the process of protein synthesis in a microbial cell (having good lipophilicity, penetrates through the bacterial cell membrane and back binds to the subunit 50S bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis).It is active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, sulfonamides. Promotes the purification and healing of burn wounds and trophic ulcers, accelerates epithelization.

Indications:

Bacterial skin infections caused by sensitive microorganisms, incl. infected burns (superficial and limited deep), bedsores, trophic ulcers, wounds, boils.

Contraindications:

Hypersensitivity to the drug components, pregnancy and lactation period, oppression of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, hepatic, renal failure, skin diseases (fungal diseases, psoriasis, eczema), neonatal period (up to 4 weeks).

Carefully:

Early childhood, previous treatment with cytostatic drugs or radiation therapy.

Dosing and Administration:

External, damaged areas are treated with a cotton swab dipped in a solution, several times a day. Duration of treatment is 2-5 days.

Side effects:

Allergic reactions: skin rash, angioedema.

On the part of the organs of hematopoiesis: rarely - thrombocytopenia, reticulocytopenia, leukopenia, granulocytopenia, erythropenia, aplastic anemia, agranulocytosis.

Interaction:

With simultaneous use with erythromycin, clindamycin, linkomycin, there is a mutual weakening of the effect due to the fact that chloramphenicol can displace these drugs from the bound state or interfere with their binding to the subunit 50S bacterial ribosomes. Reduces the antibacterial effect of penicillins and cephalosporins.

Drugs that inhibit bone marrow hematopoies increase the risk of myelosuppression.

Special instructions:

During the treatment, a systematic control of the peripheral blood pattern is necessary. With caution appoint patients who received prior treatment with cytostatic drugs or radiation therapy. With the simultaneous administration of ethanol, it is possible to develop a disulfiram-like reaction (skin flushing, tachycardia, nausea, vomiting, reflex cough, convulsions).

Form release / dosage:

Solution for external use (alcohol) 1%.

Packaging:

For 25 ml in bottles of dark glass. Each bottle with the instruction is placed in a pack of cardboard.

Storage conditions:

List B. In the dark place at a temperature of 12 to 15 ° C.

Keep out of the reach of children.

Shelf life:

1 year.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-001147/10

Date of registration:18.02.2010

Expiration Date:Unlimited

The owner of the registration certificate:KAZAN PHARMACEUTICAL FACTORY, CJSC KAZAN PHARMACEUTICAL FACTORY, CJSC Russia

Manufacturer: & nbsp

KAZAN PHARMACEUTICAL FACTORY, CJSC Russia

Information update date: & nbsp07.03.2018

Illustrated instructions

Instructions

Levomycetin (Levomycetin)