Levomycetin - instructions for use, dose, side effects, contraindications

Chloramphenicol is a bacteriostatic broad-spectrum antibiotic that disrupts the process of protein synthesis in a microbial cell (having good lipophilicity, penetrates the bacterial cell membrane and back binds to the subunit 50s bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis). It is active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, sulfonamides; promotes the purification and healing of burn purulent wounds and trophic ulcers, accelerates epithelization.Does not affect acid-fast bacteria (incl. Mycobacterium tuberculosis), anaerobes, methicillin-resistant strains of staphylococci, Acinetobacter spp., Enterobacter spp., Serratia marcescens, indol-positive strains Proteus spp., Pseudomonas aeruginosa ssp., protozoa, fungi and viruses.

Pharmacokinetics:

The degree of systemic action after application of the drug on the skin is unknown.

Indications:

Bacterial skin infections caused by sensitive microorganisms, incl. infected burns (superficial and delimited deep), pressure sores, trophic ulcers, wounds, boils.

Contraindications:

Individual intolerance, oppression of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, hepatic and / or renal failure, skin diseases (psoriasis, eczema, fungal diseases).

Carefully:

Newborn period (up to 4 weeks) and early childhood; in patients who received previous treatment with cytostatic drugs or radiation therapy.

Pregnancy and lactation:

After consulting a doctor, the drug may be administered according to the instructions if the expected benefit to the mother exceeds the potential risk to the fetus and the baby.

Dosing and Administration:

Outwardly.Damaged areas are treated with a cotton swab dipped in a solution several times a day.

Side effects:

Allergic reactions: skin rash, angioedema.

On the part of the organs of hematopoiesis: rarely - reticulocytopenia, leukopenia, granulocytopenia, thrombocytopenia, erythropenia, aplastic anemia, agranulocytosis.

Overdose:

Not found.

Interaction:

With simultaneous use with erythromycin, clindamycin, lincomycin, there is a mutual weakening of the effect due to the fact that chloramphenicol can displace these drugs from the bound state or interfere with their binding to the subunit 50S bacterial ribosomes. Reduces the antibacterial effect of penicillins and cephalosporins.

Special instructions:During the treatment, systematic monitoring of the peripheral blood pattern is necessary. With caution appoint patients who received prior treatment with cytostaticallyor radiotherapy. When applied to large surfaces with simultaneous intake of ethanol, a disulfiram-like reaction may develop (hyperemia of the skin, tachycardia, nausea, vomiting, reflex coughing, convulsions).Children of the first 4 weeks of life are appointed only in case of emergency.

Effect on the ability to drive transp. cf. and fur:

The use of the drug in accordance with the instructions does not affect the management of vehicles and occupations of potentially hazardous activities requiring increased concentration and speed of psychomotor reactions.

Form release / dosage:Solution for external use alcohol 1%.

Packaging:

To 25 or 40 ml in bottles of orange glass or 25 ml in bottles of droppers of orange glass. Vials / flasks-droppers with an equal number of instructions for use are placed in a group package.

Storage conditions:

Protected from light at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:P N002763 / 01

Date of registration:08.09.2009 / 18.05.2012

Expiration Date:Unlimited

The owner of the registration certificate:YAROSLAVSK PHARMACEUTICAL FACTORY, CJSC YAROSLAVSK PHARMACEUTICAL FACTORY, CJSC Russia

Manufacturer: & nbsp

YAROSLAVSK PHARMACEUTICAL FACTORY, CJSC Russia

Information update date: & nbsp07.03.2018

Illustrated instructions

Instructions

Levomycetin (Levomycetin)