Synthomycin - instructions for use, doses, side effects, contraindications

Excipients: castor oil ordinary seeds - 20 g, emulsifier No. 1 - 3-5 g, sorbic acid - 0.2 g, carmellose sodium grade 70/450 "O" - 1.84 g, water purified to 100 g.

Description:

Liniment of white or slightly yellowish color, with a weak odor.

Pharmacotherapeutic group:Antibiotic

ATX: & nbsp

D.06.A.X.02 Chloramphenicol

S.01.A.A.01 Chloramphenicol

J.01.B.A.01 Chloramphenicol

Pharmacodynamics:

A bacteriostatic broad-spectrum antibiotic, the left- and right-handed isomer of chloramphenicol. Disrupts the process of protein synthesis in a microbial cell (having good lipophilicity, penetrates through the bacterial cell membrane and reversibly binds to the subunit 50S bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis).

It is active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines,sulfonamides; promotes the purification and healing of burn wounds and trophic ulcers, accelerates epithelization.

Pharmacokinetics:

The degree of systemic action after application of the drug on the skin is unknown.

Indications:

Infected wounds in II phase of wound process (absence of pus, necrotic tissues), caused by sensitive microorganisms; burns of 2-3 degrees; long-term non-healing, trophic ulcers.

Contraindications:

Individual, intolerance, oppression of bone marrow hematopoiesis, acute intermittent porphyria, glucose deficiency-6-phosphate dehydrogenase, hepatic and / or renal failure, skin diseases: (psoriasis, eczema, fungal lesions), pregnancy, lactation period, neonatal period (up to 4 weeks).

Due to the absence of osmotic activity (oil base, emulsifier) it is not recommended to apply in the first phase of the wound process (copious gnotechenie, pronounced swelling of the tissues, pain and the presence of necrotic tissues).

Carefully:

Early childhood; in patients who received previous treatment with cytostatic drugs or radiotherapy.

Dosing and Administration:Outwardly.After surgical treatment of wounds and burns, the liniment is applied directly to the wound surface (after which a sterile gauze dressing is applied) or to the dressing material, and then to the wound. Tampons with liniment loosely fill the cavity of the wound after their surgical treatment; gauze turundas with liniment injected into the fistula. Multiplicity of application - 1 time in 1 -3 days, depending on the dynamics of wound healing.

Side effects:

Allergic reactions are possible: skin rash, angioedema.

From the hemopoiesis: rarely - reticulocytopenia, leukopenia, granulocytopenia, thrombocytopenia, erythropenia, aplastic anemia, agranulocytosis.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, inform the doctor about it.

Overdose:

Cases of overdose with the recommended method of use of the drug are not known.

Interaction:

With simultaneous use with erythromycin, clindamycin, lincomycin, mutual weakening of action is possible due to the fact that D, L-chloramphenicol can prevent their binding to the subunit 50S bacterial ribosomes.

Reduces the antibacterial effect of penicillins and cephalosporins.

Special instructions:

During the treatment, systematic monitoring of the peripheral blood pattern is necessary. When applied to extensive surfaces with simultaneous intake of ethanol, disulfiram-like reactions may develop (skin flushing, tachycardia, nausea, vomiting, reflex cough, convulsions).

Form release / dosage:Liniment 10%.

Packaging:

25 grams per aluminum tube. Each tube together with the instruction for use is placed in a pack of cardboard.

Storage conditions:

At a temperature not exceeding 20 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-000051

Date of registration:24.02.2011

The owner of the registration certificate:MUROMSKY INSTRUMENT-MAKING PLANT, OJSC MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia

Manufacturer: & nbsp

MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia

Information update date: & nbsp23.09.2015

Illustrated instructions

Instructions

Synthomycin (Synthomycin)