Levomycetin - instructions for use, dose, side effects, contraindications

Bacteriostatic broad spectrum antibiotic, gives the protein synthesis in the microbial cell (having a liposoluble penetrates the cell membrane bacteria and reversibly binds to the 50S subunit of the bacterial ribosome, which is delayed movement of amino acids to growing peptide chains, which leads to violation of protein synthesis). It is effective against strains of bacteria that are resistant to penicillin, tetracycline, sulfonamides. Active against Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Enterobacter species and some Neisseria, Staphylococcus aureus, Streptococcus spp. (Including Streptococcus pneumoniae, Streptococcus hemolyticus), Moraxella lacunata, rickettsiae and mycoplasmas.

Ineffective against Pseudomonas aeruginosa, Serratia marcescens.

Pharmacokinetics:

When instillation drug in the conjunctival sac creates enoughconcentration in the aqueous humor of the eye, partially enters the systemic circulation.

Indications:

Bacterial eye infections caused by sensitive microflora:

-conjunctivitis;

-keratite;

-blepharitis, blepharoconjunctivitis;

-keroconjunctivitis;

Neuroparalytic keratitis with the presence of a secondary bacterial infection.

Contraindications:

- Hypersensitivity to the components of the drug;

- oppression of bone marrow hematopoiesis;

- acute intermittent porphyria;

- deficiency of glucose-6-phosphate dehydrogenase;

- Hepatic and / or renal failure.

Carefully:

- Diseases of the skin (psoriasis, eczema, fungal lesions);

- period of newborns (up to 4 weeks) and early childhood (up to 3 years);

- patients who received previous treatment with cytostatic drug means or radiotherapy.

Pregnancy and lactation:

Contraindicated in pregnancy and during breastfeedingtion. If it is necessary to prescribe the drug to women during lactation, the question of interrupting breastfeeding should be resolved.

Dosing and Administration:

Buried in the conjunctival sac 1 to 2 drops every 1-4 hours. The drug is used no more than 10 days. According to the decision of the attending physician, treatment can be extended individually for each patient up to 3 weeks.

Side effects:

Local allergic reactions.

With long-term use: reticulocytopenia, leukopenia, granulocytesinging, thrombocytopenia, erythrocytopenia; aplastic anemia, agranulocytosis; secondary fungal infection.

Overdose:Data on drug overdose are absent.

Interaction:

Simultaneous administration with medications that depress hemopoiesis (sulfonamides, cytostatics), affecting the metabolism in the liver; with radiotherapy increases the risk of side effects.

With simultaneous use with erythromycin, clindamycin, lincomic notes a mutual weakening of the action due to the fact that chloramphenicol may interfere with their binding to the 50S subunit of bacterial ribosomes.

When administered with oral hypoglycemic drugs, their effect is noted by the suppression of metabolism in the liver and increase in their concentration in the plasma.

Chloramphenicol suppresses the enzymatic system of cytochrome P450, therefore, when used with phenobarbital, phenytoin, indirect anticoagulants, there is a weakening of the metabolism of these drugs, a slowing of the elimination and an increase in their concentration in the plasma.Reduces the antibacterial effect of penicillins and cephalosporins.

Special instructions:

There is some information about the development of bone marrow hypoplasia after the application of ophthalmic forms (in the process of treatment, a systematic control of the peripheral blood pattern is necessary).

Be wary appoint patients who received previous treatment with cytostatic drugs or radiation therapy.

Form release / dosage:Eye drops 0.25%.

Packaging:

By 5 ml in bottles of a glass tube, sealed with rubber stoppers medical with the subsequent obatkoy with aluminum caps or 5 or 10 ml in polymer bottles, sealedwith stoppers andcushions.

1 bottle of glass tube and lid-a dropper or 1 bottle of polymer, hermetDried traffic jameth and screw cap with Instructions for use are placed in a cardboard pack.

Storage conditions:

In the place protected from light. PAt a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

2 of the year.

After opening the vial, use within 30 days.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-002068

Date of registration:01.11.2011 / 08.11.2012

Expiration Date:Unlimited

The owner of the registration certificate:TATHIMFARMPREPARATY, JSC TATHIMFARMPREPARATY, JSC Russia

Manufacturer: & nbsp

TATHIMFARMPREPARATY, JSC Russia

Information update date: & nbsp11.03.2018

Illustrated instructions

Instructions

Levomycetin (Levomycetin)