Synthomycin - instructions for use, doses, side effects, contraindications

Active substance: D, L - Chloramphenicol 10.0 g; auxiliary substances: castor oil - 20.0 g, emulsifier №1 (Lanette EsX) - 5,0 g, sorbic acid - 0,2 g, carmellose sodium - 1,98 g, purified water - up to 100 g.

Description:

Liniment of white or white with a yellowish tint of color with a weak specific odor.

Pharmacotherapeutic group:antibiotic

ATX: & nbsp

D.06.A.X.02 Chloramphenicol

S.01.A.A.01 Chloramphenicol

J.01.B.A.01 Chloramphenicol

Pharmacodynamics:A bacteriostatic broad-spectrum antibiotic, the left- and right-handed isomer of chloramphenicol. Disrupts the process of protein synthesis in a microbial cell (having good lipophilicity, penetrates through the bacterial cell membrane and reversibly binds to the subunit 50S bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis). It is active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, sulfonamides. Promotes the purification and healing of burn wounds and trophic ulcers, accelerates epithelization.

Pharmacokinetics:The degree of systemic action after application to the skin is unknown.

Indications:

Infected wounds in the II phase of the wound process (absence of pus, necrotic tissues) caused by sensitive microorganisms: burns of 2-3 degrees, long-lasting non-healing trophic ulcers.

Contraindications:

Hypersensitivity, pregnancy, the period of breastfeeding, the period of newborns (up to 4 weeks), oppression of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, hepatic and / or renal failure, skin diseases (fungal lesions, psoriasis, eczema), I phase of wound process (due to lack of osmotic activity).

Carefully:

Early childhood, as well as in patients who received previous treatment with cytostatic drugs or radiotherapy.

Dosing and Administration:

Outwardly. After surgical treatment of wounds and burns, the liniment is applied directly to the wound surface, then a sterile gauze dressing is applied or the liniment is applied to the dressing and then to the wound.Tampons with liniment loosely fill the cavities of purulent wounds after their surgical treatment, and gauze turuns with the drug are injected into the fistulous passages. Multiplicity of application - 1 time in 1-3 days, depending on the dynamics of healing.

Side effects:

Allergic reactions - skin rash, angioedema.

On the part of the organs of hematopoiesis: rarely - reticulocytopenia, leukopenia, granulocytopenia, thrombocytopenia, erythropenia, aplastic anemia, agranulocytosis.

Overdose:

Cases of overdose were not observed.

Interaction:

When simultaneous application with erythromycin, clindamycin, lincomycin, possible mutual weakening of the effect due to the fact that chloramphenicol can displace these drugs from the bound state or prevent their binding to the 50S subunit of bacterial ribosomes. Reduces the antibacterial effect of penicillins and cephalosporins.

Special instructions:

During the treatment, systematic monitoring of the peripheral blood pattern is necessary. When applied to extensive surfaces with simultaneous intake of ethanol, disulfiram-like reactions may develop (skin flushing, tachycardia, nausea, vomiting, reflex cough, convulsions).

Effect on the ability to drive transp. cf. and fur:The drug does not adversely affect the performance of potentially hazardous activities requiring special attention and quick reactions (driving, etc.).

Form release / dosage:Liniment 10%

Packaging:

25 grams in aluminum tubes with bushon. One tube together with instructions for medical use in a pack of cardboard.

For treatment and prophylactic institutions, 0.1 kg; 0,5 kg; 1.0 kg; 1.5 kg; 2.0 kg; 2.5 kg; 3.0 kg; 5.0 kg; 10.0 kg or 20.0 kg in polymer cans with a lid.

Storage conditions:

In a dry, dark place at a temperature of 2 to 15 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:P N003982 / 01

Date of registration:04.02.2010

The owner of the registration certificate:GREEN DUBRAVA, CJSC GREEN DUBRAVA, CJSC Russia

Manufacturer: & nbsp

GREEN DUBRAVA, CJSC Russia

Illustrated instructions

Instructions

Synthomycin (Synthomycin)