Levomycetin - instructions for use, dose, side effects, contraindications

A bacteriostatic broad-spectrum antibiotic disrupts protein synthesis in a microbial cell (having fat-solubility, penetrates through the bacterial cell membrane and reversibly binds to the subunit 50S bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis). It is effective against strains of bacteria that are resistant to penicillin, tetracycline, sulfonamides. Active with respect to Neisseria gonorrhoeae, Chlamydia trachomatis, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, some species Enterobacter and Neisseria, Staphylococcus aureus, Streptococcus spp. (at t.ch.. Streptococcus pneumoniae, Streptococcus haemolyticus), Moraxella lacunata, rickettsia and mycoplasmas.

Ineffective against acid-fast bacteria, anaerobes, Acinetobacter spp., Serratia marcescens.

Pharmacokinetics:

When the drug is instillated into the conjunctival sac, therapeutic concentrations of chloramphenicol are created in the vitreous, cornea, iris, watery eye moisture; the drug does not penetrate into the lens. Partially enters the systemic circulation. It is excreted mainly with urine, mainly in the form of inactive metabolites; partly with bile and feces.

Indications:

Bacterial infections of the eye caused by sensitive microflora: conjunctivitis, keratitis, blepharitis, blepharoconjunctivitis, keratoconjunctivitis, neuroparalytic keratitis in the presence of secondary bacterial infection.

Contraindications:

Levomycetin is contraindicated in patients with hypersensitivity to chloramphenicol, thiamphenicol, azidamphenicol, oppression of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, renal and / or hepatic insufficiency, pregnancy, lactation, neonatal period (up to 4 weeks).

Carefully:

Skin diseases (psoriasis, eczema, fungal lesions), early childhood, in patients who received previous treatment with cytostatic drugs or radiation therapy.

Dosing and Administration:

Locally. Adults and children are instilled in the conjunctival sac 1 drop 3-4 times a day. The drug is used no more than 10 days. Prolongation of treatment is possible only according to the doctor's prescription.

Side effects:

Perhaps the development of local allergic reactions.

With prolonged use:

- reticulocytopenia;

- leukopenia;

- granulocytopenia;

- thrombocytopenia;

-Erythrocytopenia;

- aplastic anemia;

- agranulocytosis;

- secondary fungal infection.

Overdose:Data on drug overdose are absent.

Interaction:

Simultaneous use with drugs that depress hemopoiesis (sulfonamides, cytostatics) that affect metabolism in the liver; with radiotherapy increases the risk of side effects. With simultaneous use with erythromycin, clindamycin, lincomycin, there is a mutual weakening of the effect due to the fact that chloramphenicol can interfere with their binding to the subunit 50S bacterial ribosomes. Reduces the antibacterial effect of penicillins and cephalosporins.

Special instructions:

There is some information about the development of bone marrow hypoplasia after the application of ophthalmic forms (in the process of treatment it is necessarysystematic monitoring of the picture of peripheral blood).

Effect on the ability to drive transp. cf. and fur:

no data.

Form release / dosage:Eye drops 0.25%.

Packaging:

By 5 ml or 10 ml in a bottle - droppers polymer with a screw mouth, a stopper-dropper and a screw cap with the control of the first opening. 1 bottle-dropper polymer together with the instruction for use is placed in a pack of cardboard.

Storage conditions:

In a cool, dark place. Keep out of the reach of children.

Shelf life:

2 years. After opening the vial, use the solution for 30 days. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N002695 / 01

Date of registration:07.08.2008 / 03.05.2012

Expiration Date:Unlimited

The owner of the registration certificate:Pharmaceutical firm LEKKO, ZAO Pharmaceutical firm LEKKO, ZAO Russia

Manufacturer: & nbsp

Pharmaceutical firm LEKKO, ZAO Russia

Information update date: & nbsp29.09.2016

Illustrated instructions

Instructions

Levomycetin (Levomycetin)