Active substanceChloramphenicolChloramphenicol
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  • Dosage form: & nbspVaginal suppositories
    Composition:

    1 the suppository contains:

    Active substances: chloramphenicol (synthomycin) 0.25 g;

    Excipients: bases for suppositories: solid fat, type A - sufficient amount to obtain a suppository with a mass of 1.71-1.89 g.

    Description:Suppositories white or white with a yellowish or kremovatym shade of color, torpedo-shaped. In the section, an air rod is allowed.
    Pharmacotherapeutic group:antibiotic
    ATX: & nbsp

    D.06.A.X.02   Chloramphenicol

    S.01.A.A.01   Chloramphenicol

    J.01.B.A.01   Chloramphenicol

    Pharmacodynamics:

    Chloramphenicol is a bacteriostatic broad-spectrum antibiotic that disrupts the process of protein synthesis in a microbial cell (possessing good lipophilicity, penetrates through the bacterial cell membrane and reversibly binds to the subunit 50S bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis). It is active against most strains of gram-positive and gram-negative bacteria, pathogens of purulent, intestinal infections, meningococcal infection: Escherichia coli, Shigella dysenteria, Shigella flexneri spp., Shigella boydii spp., Shigella sonnei, Salmonella spp. ( in t.ch. Salmonella typhi, Salmonella paratyphi), Staphylococcus spp., Streptococcus spp. (incl. Streptococcus pneumoniae), Neisseria meningitides, Neisseria gonorrhoeae, a number of strains Proteus spp., Burkholderia pseudomallei, Rickettsia spp., Treponema spp., Leptospira spp., Chlamydia spp. (incl. Chlamydia trachomatis), Coxiella burnetii, Ehrlichia canis, Bacteroides ffagilis, Klebsiella pneumoniae, Haemophilus influenzae.

    He acts on acid-fast bacteria (incl. Mycobacterium tuberculosis), anaerobes, methicillin-resistant strains of staphylococci, Acinetobacter, Enterobacter, Serratia marcescens, indol-positive strains Proteus spp., Pseudomonas aeruginosa spp., protozoa and fungi. Stability of microorganisms to chloramphenicol develops slowly.

    Indications:Bacterial pelvic infections caused by sensitive microorganisms(vaginitis, cervicitis). Prevention of purulent-inflammatory diseases in ginon -ology (before invasive procedures: abortion, gynecological operations (cervical diathermocoagulation, hysterography), before and after installation of the intrauterine device).

    Contraindications:

    Hypersensitivity to drug components, oppression of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, hepatic and / or renal failure, fungal diseases of the vagina, pregnancy and lactation. Do not use the drug in girls before the onset of puberty.

    Dosing and Administration:

    Intravaginal.Preliminarily releasing the suppository from the outline package, it is injected, lying on its back, deep in the vagina, 1 suppository 2-3 times a day. The maximum daily dose is 4 suppositories. For girls who have reached puberty, the drug is prescribed 1 suppository 1-2 times a day.

    The average duration of treatment is 8-10 days.

    Side effects:

    Burning sensation during urination or frequent urination, itching, burning pain or hyperemia of the mucous membrane of the vulva, burning or irritation of the penis in the sexual partner, dysbacteriosis of the vagina.

    Interaction:

    Reduces the antibacterial effect of penicillins and cephalosporins. With simultaneous use with erythromycin, clindamycin, lincomycin, there is a mutual weakening of the effect.

    Form release / dosage:

    Vaginal suppositories 250 mg.

    Packaging:

    There are 5 suppositories in a contiguous cell package. 2 contour mesh packages together with instructions for use in a pack of cardboard.

    Storage conditions:

    List B. In a dry, protected from light place, at a temperature of no higher than 15 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-004426/09
    Date of registration:04.06.2009
    The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia
    Manufacturer: & nbsp
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