Levomycetin - instructions for use, dose, side effects, contraindications

Pharmacodynamics:The active substance of the drug is chloramphenicol - a broad-spectrum antibiotic with high antibacterial activity against the causative agent of wound infection and various forms of purulent-inflammatory processes. Chloramphenicol - bacteriostatic antibiotic, disrupts the process of protein synthesis in a microbial cell (having good lipophilicity, penetrates through the bacterial cell membrane and back binds to the subunit 50S bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis). Active with the majority strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, sulfonamides.

Promotes purification and healing of burn purulent wounds and trophic ulcers, accelerates epithelization. Not acts on acid-fast bacteria (including Mycobacterium tuberculosis), anaerobes, methicillin-resistant Staphylococcus strains, Acinetobacter spp., Enterobacter spp., Serratia marcescens, Indol-positive strains of Proteus spp., Pseudomonas aeruginosa, protozoa, fungi and viruses.

Indications:

Bacterial skin infections caused by sensitive microorganisms, incl. infected burns (superficial and limited deep), pressure sores, trophic ulcers, boils.

Contraindications:

Individual intolerance, oppression of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, hepatic, renal failure, skin diseases (psoriasis, eczema, fungal lesions), pregnancy, breastfeeding period, neonatal period (up to 4 weeks).

Carefully:

Early childhood; in patients who received previous treatment with cytostatic drugs or radiotherapy.

Dosing and Administration:

External, damaged areas are treated with a cotton swab dipped in solution, 2-3 times a day. The duration of the course of treatment is according to the indications depending on the nature and localization of the affected area.

Side effects:

Allergic reactions: skin rash, angioedema.

On the part of the organs of hematopoiesis: reticulocytopenia, leukopenia, granulocytopenia, thrombocytopenia, erythropenia, aplastic anemia, agranulocytosis.

Overdose:

Cases of overdose are not registered.

Interaction:

With simultaneous use with erythromycin, clindamycin, lincomycin, there is a mutual weakening of the effect due to the fact that chloramphenicol can displace these drugs from the bound state or interfere with their binding to the subunit 50S bacterial ribosomes. Reduces the antibacterial effect of penicillins and cephalosporins.

Drugs that inhibit bone marrow hematopoies increase the risk of myelosuppression.

Special instructions:

During the treatment, systematic monitoring of the peripheral blood pattern is necessary.

When applied to extensive surfaces with simultaneous intake of ethanol, disulfiram-like reactions may develop (skin flushing, tachycardia, nausea, vomiting, reflex cough, convulsions).

Form release / dosage:

Solution for external use [alcohol] 1%, 3%.

Packaging:For 25 and 40 ml in bottles of orange glass with a screw mouth, sealed with stoppers and caps screwed on. To 25 ml in bottles-droppers of orange glass, ukuporennye stoppers-droppers and caps screwed. Each vial, a dropper, along with instructions for use, is placed in a pack of cardboard. The full text of the instructions for use should be applied to the pack. It is allowed to pack vials, flasks-droppers without a pack together with an equal number of instructions for use in group packaging. For 5, 10 and 20 liters in cans of polyethylene (for hospitals) with instructions for use;

Storage conditions:

AT protected from light at a temperature from 15 before 25 ° C. Keep out of the reach of children.

Shelf life:

1 year. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-001792

Date of registration:07.08.2012 / 08.08.2017

Expiration Date:Unlimited

The owner of the registration certificate:IVANOVSKAYA Pharmaceutical Factory, OAO IVANOVSKAYA Pharmaceutical Factory, OAO Russia

Manufacturer: & nbsp

IVANOVSKAYA Pharmaceutical Factory, OAO Russia

Information update date: & nbsp11.03.2018

Illustrated instructions

Instructions

Levomycetin (Levomycetin)