Levomycetin - instructions for use, dose, side effects, contraindications

The active substance of the drug is chloramphenicol - a broad-spectrum antibiotic with a high antibacterial activity against the causative agents of wound infection and various forms of purulent-inflammatory processes. Chloramphenicol - bacteriostatic antibiotic, disrupts the process of protein synthesis in a microbial cell (possessing good lipophilicity, penetrates through the bacterial cell membrane and reversibly binds to the subunit 50S bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis).It is active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines and sulfonamides. Promotes the purification and healing of burn wounds and trophic ulcers, accelerates epithelization.

Indications:

Bacterial skin infections caused by sensitive microorganisms, incl. infected burns (superficial and limited deep), bedsores, trophic ulcers, wounds, boils.

Contraindications:

Hypersensitivity to any of the components of the drug, oppression of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, liver failure, renal failure, skin diseases (fungal diseases, psoriasis, eczema), pregnancy, breastfeeding period, neonatal period up to 4 weeks).

Carefully:Early childhood, previous treatment with cytostatic drugs or radiation therapy.

Dosing and Administration:

Outwardly. Affected areas are treated with a cotton swab dipped in the solution of the drug several times a day. Duration of treatment is 2-5 days.

Side effects:

Allergic reactions (skin rash, angioedema).

On the part of the organs of hematopoiesis: thrombocytopenia, erythropenia, leukopenia, aplastic anemia, reticulocytopenia, granulocytopenia, agranulocytosis.

Overdose:

Until now, there have been no reports of cases of overdose with the use of the drug.

Interaction:

With simultaneous use with erythromycin, clindamycin, lincomycin, there is a mutual weakening of the effect due to the fact that chloramphenicol can displace these drugs from the bound state or interfere with their binding to the subunit 50S bacterial ribosomes. Reduces the antibacterial effect of penicillins and cephalosporins. Simultaneous use with drugs that inhibit bone marrow hematopoiesis (sulfonamides, cytostatics), with radiation therapy increases the risk of side effects.

Special instructions:

During the treatment, systematic monitoring of the peripheral blood pattern is necessary. When applied to extensive surfaces with simultaneous intake of ethanol, disulfiram-like reactions may develop (skin flushing, tachycardia, nausea, vomiting, reflex cough, convulsions).

Effect on the ability to drive transp. cf. and fur:The use of the drug does not affect the performance of potentially hazardous activities requiring special attention and rapid reactions

Form release / dosage:

Solution for external use [alcohol] 0.25%, 1%, 3%, 5%.

Packaging:

To 25, 40 ml of the drug in orange-glass bottles with a screw mouth, sealed with polymer caps and polymer-screw caps.

To 25, 40 ml into bottles of polyethylene terephthalate, sealed with polymer screw caps.

Each bottle, together with the instructions for use, is placed in a pack of cardboard. It is allowed to pack bottles in a group package with an equal number of instructions for use.

Storage conditions:

In the dark place at a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LP-001987

Date of registration:29.01.2013 / 25.01.2018

Expiration Date:29.01.2018

The owner of the registration certificate:TULA PHARMACEUTICAL FACTORY, LTD. TULA PHARMACEUTICAL FACTORY, LTD. Russia

Manufacturer: & nbsp

TULA PHARMACEUTICAL FACTORY, LTD. Russia

Information update date: & nbsp11.03.2018

Illustrated instructions

Instructions

Levomycetin (Levomycetin)