Levomycetin - instructions for use, dose, side effects, contraindications

A bacteriostatic broad-spectrum antibiotic disrupts the process of protein synthesis in a microbial cell (having fat-solubility, penetrates through the bacterial cell membrane and reversibly binds to the subunit 50S bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis). It is effective against strains of bacteria that are resistant to penicillin, tetracycline, sulfonamides.

Active with respect to Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, some species Enterobacter and Neisseria, Staphylococcus aureus, Streptococcus spp. (in tons. h. Streptococcus pneumoniae, Streptococcus haemolyticus), Moraxella lacunata, rickettsia and mycoplasmas.

Heis effective against acid-fast bacteria, anaerobes, Acinetobacter spp., Pseudomonas aeruginosa, Serratia marcescens.

Pharmacokinetics:

When the drug is instillated into a conjunctival sac, therapeutic concentrations are created in the aqueous humor of the eye, the cornea, the iris, the vitreous humor; in the lens does not penetrate. Partially enters the systemic circulation. It is excreted mainly by the kidneys in the form of inactive metabolites, partly by the intestine.

Indications:

Bacterial eye infections caused by sensitive microflora:

- conjunctivitis;

- keratitis;

- blepharitis;

- blepharoconjunctivitis;

- keratoconjunctivitis;

- Neuroparalytic keratitis in the presence of secondary bacterial infection.

Contraindications:Increased individual sensitivity to the components of the drug; oppression of bone marrow hematopoiesis; acute intermittent porphyria; deficiency of glucose-6-phosphate dehydrogenase; hepatic and / or renal insufficiency; pregnancy, lactation; Newborn period (up to 4 weeks).

Carefully:

Diseases of the skin (psoriasis, eczema, fungal lesions); early childhood; patients who received previous treatment with cytostatic drugs or radiation therapy.

Pregnancy and lactation:

The use of the drug is contraindicated during pregnancy and during breastfeeding.

Dosing and Administration:

Locally.

Adults and children are instilled in the conjunctival sac by 1-2 drops every 1-4 hours. The recommended course of treatment is 7-10 days. Prolongation of treatment is possible by appointment of a doctor.

Side effects:

Local allergic reactions.

With long-term use: reticulocytopenia, leukopenia, granulocytopenia, thrombocytopenia, erythrocytopenia; rarely - aplastic anemia, agranulocytosis; secondary fungal infection.

Overdose:

Data on drug overdose are absent.

Interaction:

Simultaneous appointment with drugs that oppress hemopoiesis (sulfonamides, cytostatics), affecting the metabolism in the liver; with radiotherapy increases the risk of side effects.

With simultaneous use with erythromycin, clindamycin, lincomycin, there is a mutual weakening of the effect due to the fact that chloramphenicol can displace these drugs from the bound state or prevent their binding to the subunit 50S bacterial ribosomes.

When administered with oral hypoglycemic drugs, their effect is noted to be enhanced by suppressing the metabolism in the liver and increasing their concentration in the plasma.

Chloramphenicol suppresses the cytochrome P450 enzyme system, so when used with phenobarbital, phenytoin, indirect anticoagulants, there is a weakening of the metabolism of these drugs, a slowdown in the excretion and an increase in their concentration in the plasma.

Reduces the antibacterial effect of penicillins and cephalosporins.

Special instructions:

There is some information about the development of bone marrow hypoplasia after the application of ophthalmic forms (during the treatment, systematic monitoring of the peripheral blood pattern is necessary).

After opening, use within 14 days.

Effect on the ability to drive transp. cf. and fur:

In the event that the patient after application of the drug temporarily reduces the clarity of visual perception, it is not recommended to drive vehicles and engage in other potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions before recovery.

Form release / dosage:

Eye drops, 0,25%.

Packaging:

1 ml, 1.5 ml, 2 ml in a dropper with a valve or 5 ml, 10 ml in a tube with a screw mouth of polyethylene.

Tube-dropper with a screw neck is capped with screw caps made of polymer materials.

2 tubes of a dropper for 1 ml, 1.5 ml, 2 ml or 5 tubes for 1 ml, 2 ml, or 1 tube of a dropper for 5 ml, 10 ml with instructions for use are placed in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of 2 to 15 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LP-003772

Date of registration:10.08.2016

Expiration Date:10.08.2021

The owner of the registration certificate:UPDATE OF PFC, CJSC UPDATE OF PFC, CJSC Russia

Manufacturer: & nbsp

UPDATE, PFC CJSC Russia

Representation: & nbspUPDATE OF PFC, CJSCUPDATE OF PFC, CJSC

Information update date: & nbsp07.03.2018

Illustrated instructions

Instructions

Levomycetin (Levomycetin)