Active substanceChloramphenicolChloramphenicol
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  • Dosage form: & nbspliniment
    Composition:

    Active substances: Synthomycin (chloramphenicol) - 10 g. auxiliary substances: castor oil, emulsifier No.1, sorbic acid, sodium carboxymethyl cellulose, purified, purified water.

    Description:Liniment of white or slightly yellowish color with a weak odor.
    Pharmacotherapeutic group:Antibiotic
    ATX: & nbsp

    D.06.A.X.02   Chloramphenicol

    S.01.A.A.01   Chloramphenicol

    J.01.B.A.01   Chloramphenicol

    Pharmacodynamics:

    Antibiotic of a wide spectrum of action, possesses high antibacterial activity in relation to the causative agent of wound infection and various forms of purulent-inflammatory processes.

    Chloramphenicol is a bacteriostatic antibiotic that disrupts the process of protein synthesis in a microbial cell (having good lipophilicity, penetrates through the bacterial cell membrane and back binds to the subunit 50S bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis).It is active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, sulfonamides. Promotes the purification and healing of burn wounds and trophic ulcers, accelerates epithelization.

    Indications:

    Treatment of wounds in the second phase of the wound process (absence of pus, necrotic tissues), long-term non-healing trophic ulcers, burns of 2-3 degrees.

    Contraindications:

    Individual intolerance, pregnancy and lactation, oppression of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, hepatic and / or renal failure, skin diseases (fungal diseases, psoriasis, eczema).

    In view of the absence of osmotic activity (oil base, emulsifier), it is not recommended to apply in the first phase of the wound process (copious gnotechenie, pronounced edema of the tissues, pain and the presence of necrotic tissues).

    Carefully:The period of neonatal (up to 4 weeks) and early childhood, previous treatment with cytostatic drugs or radiation therapy.
    Dosing and Administration:

    Locally.After surgical treatment of wounds and burns, the liniment of sintomycin is applied directly to the wound surface, after which a sterile gauze dressing is applied and the liniment of the shintomycin is applied to the dressing and then to the wound. Tampons with liniment loosely fill the cavities of purulent wounds after their surgical treatment, and gauze turundas with liniment of synthomycin are injected into the fistulous passages.

    In the treatment of wounds and burns in the 2 nd phase - 1 time in 1-3 days, depending on the dynamics of wound healing.

    Side effects:Allergic reactions: skin rash, angioedema. From the hemopoiesis: rarely - reticulocytopenia, thrombocytopenia, erythropenia, aplastic anemia, granulocytosis, leukopenia, agranulocytosis
    Interaction:

    With simultaneous use with erythromycin, clindamycin, lincomycin, there is a mutual weakening of the effect due to the fact that chloramphenicol can displace these drugs from the bound state or prevent their binding to the subunit 5 OS bacterial ribosomes.

    Reduces the antibacterial effect of penicillins and cephalosporins.

    Special instructions:

    During the treatment, systematic monitoring of the peripheral blood pattern is necessary. With caution appoint patients who received prior treatment with cytostatic drugs or radiation therapy. With the simultaneous administration of ethanol, a disulfiram-like reaction may develop (skin flushing, tachycardia, nausea, vomiting, reflex cough, seizures).

    Form release / dosage:10% liniment.
    Packaging:

    By 25, 35 g in aluminum tubes or 25, 40, 50, 800, 1800 g in cans of glass glass of orange glass. Tubes and cans of 25, 40, 50 g, together with instructions for use, are placed in a group package. 8 cans of 800 g and 4 cans of 1800 g together with instructions for use are placed in a box of corrugated cardboard (for hospitals).

    Storage conditions:In a dry place, protected from light, inaccessible to children, at a temperature not exceeding 15 FROM.
    Shelf life:

    2 years. Do not use after the time specified on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LS-000694
    Date of registration:06.08.2010
    The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia
    Manufacturer: & nbsp
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