Individual intolerance, pregnancy and lactation, oppression of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, hepatic and / or renal failure, skin diseases (fungal diseases, psoriasis, eczema).
In view of the absence of osmotic activity (oil base, emulsifier), it is not recommended to apply in the first phase of the wound process (copious gnotechenie, pronounced edema of the tissues, pain and the presence of necrotic tissues).