Synthomycin - instructions for use, doses, side effects, contraindications

Excipients:castor oil - 200.0 mg, emulsifier # 1 - 30.0-50.0 mg, sorbic acid 2.0 mg, ethanol -8.1 mg in terms of alcohol 96%, carmellose sodium - 18.4 mg in terms of the degree of polymerization of 400-500, water - up to 1 g.

Description:

Liniment is white or white with a yellowish tint of color, with a weak specific odor.

Pharmacotherapeutic group:antibiotic

ATX: & nbsp

D.06.A.X.02 Chloramphenicol

S.01.A.A.01 Chloramphenicol

J.01.B.A.01 Chloramphenicol

Pharmacodynamics:

The active substance of the drug is chloramphenicol - a broad-spectrum antibiotic with high antibacterial activity against the causative agent of wound infection and various forms of purulent-inflammatory processes.

Chloramphenicol is a bacteriostatic antibiotic that disrupts the process of protein synthesis in a microbial cell (possessing high lipophilicity, penetrates through the bacterial cell membrane and reversibly binds to the subunit 50S bacterial ribosomes, as a result, the movement of amino acids to growing peptide chains is delayed, which leads to disruption in the formation of peptide bonds and protein synthesis). It is active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, sulfonamides. Promotes the purification and healing of burn wounds and trophic ulcers, accelerates epithelization.

Pharmacokinetics:The degree of absorption to the systemic circulation after application of the drug to the skin, wounds or mucous membranes is unknown.

Indications:

Infected wounds in II phase of wound process (absence of pus, necrotic tissues), long-lasting non-healing trophic ulcers, burns of 2-3 degrees.

Contraindications:

Individual intolerance, oppression of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, hepatic and / or renal failure, skin diseases (fungal lesions, psoriasis, eczema), pregnancy, lactation period, neonatal period (up to 4 weeks).

In view of the absence of osmotic activity (base: oil,emulsifier) is not recommended for use in the first phase of the wound process (copious suppuration, severe swelling of the tissues, pain and presence of necrotic tissues).

Carefully:

Early childhood, in patients who received previous treatment with cytostatic drugs or radiotherapy.

Dosing and Administration:

Outwardly. After surgical treatment of wounds and burns, the liniment of the synthomycin is applied directly to the wound surface, after which a sterile gauze dressing is applied or the shintomycin liniment is applied to the dressing and then to the wound. Tampons with liniment loosely fill the cavities of purulent wounds after their surgical treatment, and gauze turundas with liniment of synthomycin are injected into the fistulous passages.

In the treatment of wounds and burns in the 2 nd phase - 1 time in 1-3 days, depending on the dynamics of wound healing.

Side effects:

Allergic reactions are possible: skin rash, angioedema.

On the part of the organs of hematopoiesis: rarely - reticulocytopenia, leukopenia, granulocytopenia, thrombocytopenia, erythropenia, aplastic anemia, agranulocytosis.

Interaction:

With simultaneous use with erythromycin, clindamycin, lincomycin, mutual weakening of the action is possible due to the fact that chloramphenicol can displace these drugs from the bound state or interfere with their binding to the subunit 50S bacterial ribosomes. Reduces the antibacterial effect of penicillins and cephalosporins.

Special instructions:

During the treatment, systematic monitoring of the peripheral blood pattern is necessary. Adverse effects on the fetus during pregnancy and breastfeeding have not been revealed.

When applied to extensive surfaces with simultaneous intake of ethanol, disulfiram-like reactions may develop (skin flushing, tachycardia, nausea, vomiting, reflex cough, convulsions).

Form release / dosage:Liniment 10%.

Packaging:

25 grams per tube aluminum. 1 tube together with instructions for medical use of the drug is placed in a pack of cardboard.

Storage conditions:

At a temperature not exceeding 20 ° C.

Keep out of the reach of children

Shelf life:

2 years. Do not use the drug after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:P N003105 / 02

Date of registration:26.09.2008

The owner of the registration certificate:NIZHFARM, JSC NIZHFARM, JSC Russia

Manufacturer: & nbsp

NIZHFARM, JSC Russia

Illustrated instructions

Instructions

Synthomycin (Synthomycin)