Human albumin Biotest is administered by intravenous infusion.The drug is administered undiluted or diluted with an isotonic solution, for example, 0.9% sodium chloride solution.
When hypovolemic shock the volume and speed of infusion are selected individually, according to the condition and response of the patient to ongoing therapy. When dehydrating the patient, crystalloid solutions are additionally prescribed. The total dose should not exceed the albumin level of a healthy person, i.e. approximately 2 g per kg of body weight in the absence of active bleeding.
In the treatment burns The introduction of human albumin Biotest is usually started no earlier than 24 hours after thermal damage to maintain colloidal osmotic pressure of the plasma (in the first day large volumes of saline solutions are poured to restore a reduced volume of extracellular fluid). Conducted therapy should maintain a concentration of plasma albumins at a level of 25 ± 5 g / l with oncotic plasma pressure of 20 mm Hg. (equivalent to a total protein concentration of 52 g / l). The duration of therapy is determined by the dynamics of protein loss from the burned areas and with urine.
When hypoproteinemia Human albumin Biotest is prescribed only as a symptomatic or maintenance therapy against the background of the correction of the underlying pathology that caused this condition. The usual daily dose for adults is 50 -75 g, for children - 25 g. Patients with severe hypoproteinemia who continue to lose albumin, the dose of the drug may be increased. Because patients with hypoproteinemia usually have a normal volume of circulating blood, the infusion rate should not exceed 2 ml / min, since a faster administration can cause circulatory disorders and pulmonary edema.
When adult respiratory distress syndrome patients with clinical signs, simultaneously indicating hypoproteinemia and hypervolemia, Human albumin Biotest is prescribed in the above doses together with diuretics.
When hemolytic disease of newborns the drug is prescribed at a dose of 1 g / kg body weight 1 hour before the exchange transfusion procedure.
For resuspension of erythrocytes When transfusing the erythrocyte mass, 25 g of human albumin is used. Biotest per 1 liter of erythrocyte mass just before the transfusion of thawed washed erythrocytes.If the patient has concomitant hypoproteinemia or severe liver damage, the dose of the drug may be increased.
When acute nephrosis in the absence of response to therapy with cyclophosphamide or steroids or with worsening of edematous syndrome during therapy with steroids, there may be a combined use of 100 ml of human biotest and diuretics daily for 7-10 days under the control of diuresis and potassium concentration in the blood.
In carrying out hemodialysis The introduction of human albumin Biotest is indicated in the development of hypovolemic shock or hypotension in patients with chronic renal insufficiency. The dose of administration is usually 100 ml. It is necessary to avoid overload with the volume often observed in such patients (which is why they can not tolerate the introduction of large volumes of saline solutions).
When introducing human albumin, biotest should regularly monitor hemodynamic parameters:
- blood pressure and heart rate
- central venous pressure
- pulmonary artery pressure
- diuresis
- electrolytes
- hematocrit / hemoglobin
After opening the vial, the solution should be used immediately. Unused solution is not subject to storage.