Active substanceHuman albuminHuman albumin
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  • Dosage form: & nbspsolution for infusions
    Composition:

    Active substance:

    Human albumin 50 g / 100 g

    Excipients:

    Sodium caprylate 1.5 g / 3.0 g

    Sodium chloride 9.0 g / 9.0 g

    Water for injections up to 1 l / up to 1 l

    Pharmacotherapeutic group:Plasmasuberant
    ATX: & nbsp

    B.05.A.A.01   Albumen

    Pharmacodynamics:

    Plasma-replacing agent obtained by fractionating human blood plasma. It replenishes the deficiency of blood plasma albumin, supports the colloid-osmotic (oncotic) blood pressure, rapidly increases blood pressure and circulating blood volume, promotes fluid transfer from tissues to the bloodstream, and has detoxification properties. Albumin is a natural protein, which is an integral part of the protein fraction of human blood, with a molecular weight of 69,000 daltons.

    Indications:Shock (traumatic, operational, toxic), burns, accompanied by dehydration and "thickening" of blood; hypoproteinemia, hypoalbuminemia, developing, at alimentary dystrophy, nephrotic syndrome, glomerulonephritis, liver cirrhosis, long-term ongoing purulent processes, lesions gastrointestinal tract with impaired suction or patency.
    Contraindications:Increased individual sensitivity, hypervolemia, chronic heart failure II-IV functional class for NYHA, pulmonary edema, severe anemia.
    Carefully:Renal failure, hemorrhage, thrombosis, arterial hypertension.
    Pregnancy and lactation:Albumin solution should be used during pregnancy and during breastfeeding only if the potential The benefit to the mother exceeds the possible risk to the fetus or child.
    Dosing and Administration:

    The drug is administered by infusion. Before use, the concentration of the drug, dose and speed of infusion should be selected individually in each case. The dose required for administration depends on the body weight, the severity of the injury or disease, and the continued loss of fluid and protein. To determine the required dose, the sufficiency of BCC, rather than the level of albumin in the plasma, should be assessed.

    The average dose is -1-2 ml / kg daily or every other day until the effect is achieved.

    For 5% solution albumin an average single dose is 200-300 ml, the maximum the dose is 500-800 ml. The recommended rate of administration is not more than 60 drops / min.

    For 10% solution albumin single dose is 100 ml. The recommended rate of administration is no more than 40 drops / min.

    With exchange replacement of plasma, the infusion rate may be higher and should match the removal rate.

    In pediatric practice, albumin 10% is given in a dose of 3 ml / kg body weight.

    In children, the dose of the drug is set individually, taking into account the clinical state and body weight of the patient. The recommended single dose is 0.5-1 g / kg body weight body. In hemolytic disease of newborns, the drug is prescribed at a dose of 1 g / kg body weight 1 hour before the exchange transfusion procedure.

    The drug can be used in premature infants.

    The drug can be used in patients on hemodialysis.

    Side effects:Allergic reactions (urticaria, anaphylactic shock), chills, hyperthermia, pain in the lumbar region.
    Overdose:

    Symptoms: headache, chills, hyperthermia, pain in the lumbar region.

    Treatment: At the first clinical signs of cardiovascular overload (headache, dyspnea, jugular veins overflow) or with increased blood pressure, increased venous pressure and pulmonary edema,should immediately stop the infusion and carry out continuous monitoring of hemodynamic parameters patient.

    According to the indications - to carry out symptomatic therapy.

    If the dose or rate of administration of the infusion solution is too high, develop hypervolemia.

    Interaction:

    Compatible with standard electrolyte and carbohydrate solutions for intravenous infusion.

    The drug should not be mixed with protein hydrolysates, solutions of amino acids, with solutions containing alcohol.

    Special instructions:

    Before use, a visual inspection of the drug and packaging: the solution must be transparent, not containing any inclusions, glass packaging, should be sealed, without cracks. In the case history, it is necessary to register the label data (name of the preparation, manufacturer, serial number, production date). After opening the bottle, the solution should be used immediately. Unused solution is not subject to storage.

    Administration of the drug during dehydration; possible only after a preliminary ensuring sufficient fluid intake (inside or parenteral).

    It is necessary to constantly monitor the patient's condition to avoid overloading circulatory system or hyperhydration.

    When using drugs prepared from human plasma, it is impossible to completely eliminate the risk of transmission of known and as yet unknown virus infections.
    Form release / dosage:Solution for infusions 5% and 10%.
    Packaging:

    Solution for infusions 5% and 10% nabout 50 ml, 100 ml, 200 ml, 400 ml in bottles of glass for blood, transfusion and infusion preparations. For 1 bottle in a pack of cardboard along with instructions for use.

    Solution for infusions 10% for 10 and 20 ml in ampoules. For 10 or 5 ampoules in a pack of cardboard along with instructions for use.

    Storage conditions:At a temperature of 2 to 10 ° C. In a place inaccessible to children.
    Shelf life:5 years. Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:LS-001269
    Date of registration:06.10.2011 / 08.06.2015
    Expiration Date:Unlimited
    The owner of the registration certificate:Chelyabinsk Regional Blood Transfusion StationChelyabinsk Regional Blood Transfusion Station Russia
    Manufacturer: & nbsp
    Information update date: & nbsp14.07.2017
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