Albumin - instructions for use, dose, side effects, contraindications

Polypeptide, one of the main protein components of blood serum. Albumin is a natural protein that is an integral part of the protein fraction of human blood. The molecular weight of albumin is 69,000 Da. Normally, in human blood plasma albumin accounts for about 60%. The synthesis of albumin occurs in the liver.

Pharmacological properties

Plasma-replacing agent obtained by fractionating human plasma free from HIV-1, 2, hepatitis C viruses and the hepatitis B surface antigen. Replenishes plasma albumin deficiency, maintains colloid osmotic (oncotic) blood pressure, rapidly increases blood pressure and circulating blood volume , increases the transition and promotes retention of tissue fluid in the bloodstream, increases the reserves of protein nutrition of tissues and organs. It has detoxification properties.

Indications:

Shock (traumatic, operational and toxic); burns accompanied by dehydration and "thickening" of blood; hypoproteinemia, hypoalbuminemia, developing with alimentary dystrophy, nephrotic syndrome, glomerulonephritis, cirrhosis, long-term ongoing purulent processes, lesions of the gastrointestinal tract with impaired absorption or permeability (peptic ulcer of stomach and duodenum, tumors, impaired gastrointestinal anastomosis ); edema of the brain; operations using artificial circulation; therapeutic plasmapheresis; hemolytic disease of newborns during the exchange blood transfusion; preoperative hemodilution and the preparation of autoblood components.

Contraindications:

Hypersensitivity, severe anemia, chronic heart failure II- III stage, hypervolemia, pulmonary edema.

Carefully:Arterial hypertension, renal failure, thrombosis, ongoing internal bleeding, chronic heart failure of stage I.

Dosing and Administration:

Intravenously drip, 10% solution at a speed of no more than 40 cap / min; single dose - 200 ml.

Bolus albumin solution is permissible shocks of various origins for the rapid increase in blood pressure.

The dose is set individually depending on the indications and clinical picture or 1-2 ml / kg of a 10% solution daily until the effect is achieved.

In pediatric practice, the dosage of albumin is calculated taking into account the concentration in ml per kg of body weight of the child (not more than 3 ml / kg).

Elderly patients should avoid rapid administration of the drug because of the danger of cardiovascular overload.

Side effects:

Allergic reactions, hives, hyperthermia, pain in the lumbar region, anaphylactic shock.

Special instructions:

Before transfusion of a solution of albumin 10% the doctor should conduct a visual inspection of the preparation and its containing containers. The solution should be clear and should not contain suspended solids. The preparation is considered to be suitable for use under condition of preservation of tightness and capping, absence of cracks on vials, safety of a label. The results of visual inspection and data labels (the name of the drug, the manufacturer, batch number) are recorded in the history of the disease.

Introduction with dehydration is possible only after preliminary ensuring sufficient intake of fluid (by mouth, parenterally).

In the case of freezing during transport, the preparation can be used if, during thawing, it has not changed the appearance.

Form release / dosage:Solution for infusions 10%.

Packaging:

For 100, 200 ml in glass bottles for blood, transfusion preparations.

Each bottle, along with the instructions for use, is placed in a cardboard box.

Solution for infusions 10% in ampoules of glass for 10, 20 ml. 5 or 10 ampoules per pack together with the instructions and the knife ampoule.

Storage conditions:

At a temperature of 2 to 10 ° C out of the reach of children. List B.

Shelf life:

5 years. Do not use after the time specified on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-000790/08

Date of registration:15.02.2008

Expiration Date:Unlimited

The owner of the registration certificate:Vologda Regional Blood Transfusion Station No.1 Vologda Regional Blood Transfusion Station No.1 Russia

Manufacturer: & nbsp

Vologda Regional Blood Transfusion Station No.1 Russia

Information update date: & nbsp15.07.2017

Illustrated instructions

Instructions

Albumen (Albumin)