Active substanceHuman albuminHuman albumin
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  • Dosage form: & nbspsolution for infusions
    Composition:Composition (per 1 liter of preparation):

    Albumin 100 g
    sodium caprylate (sodium caprylic acid) 3 g
    sodium chloride 5 g
    water for injection up to 1 liter

    Description:Transparent liquid is yellow, a greenish shade is allowed.
    Pharmacotherapeutic group:Plasmasuberant
    ATX: & nbsp

    B.05.A.A.01   Albumen

    Pharmacodynamics:

    Albumin is an integral part of the protein fraction of human blood. The drug is made from a donor plasma, tested for the absence of antibodies to the human immunodeficiency virus (HIV-1, HIV-2), hepatitis C virus and the surface antigen of the hepatitis B virus.

    Albumin in the body performs the following main functions: hemodynamic (maintenance of colloid-oncotic blood pressure), sorption and transport and the function of the main protein reserve of the body.

    10% albumin solution is a weak hyperoncotic solution that maintains the oncotic pressure of the circulating blood. When it is applied to the vascular bed, the fluid from the interstitial space is attracted and retained in it, which increases and stabilizes blood pressure.

    Albumin binds and inactivates toxins,transports inside the body pigments (bilirubin), fatty acids, ions of certain metals, medicinal substances, improves tissue perfusion in diseases accompanied by hypoproteinemia, has a positive effect on protein-synthesizing function of the liver.

    Indications:

    - Hypoalbuminemia of various genesis (a decrease in albumin in the plasma below 30 g / L, or a decrease in the total protein content below 50 g / l):

    - shock hemorrhagic, traumatic, thermal;

    - acute blood loss (decrease in the volume of circulating blood by more than 25 - 30%);

    - purulent-septic conditions;

    - liver disease (with violation of albumin-synthesizing function);

    - kidney disease (nephritis, nephrotic syndrome);

    - burn disease.

    - Operations with the use of artificial circulation.

    - Therapeutic plasmapheresis.

    - Hemolytic disease of newborns during an exchange blood transfusion.

    - Conducting pre-operative hemodilution and preparing components of autoblood.

    - Edema of the brain.

    Contraindications:

    Hypersensitivity, heart failure II-B - III century. (due to the possible occurrence of acute heart failure), hypervolemia, thrombosis,severe form of arterial hypertension, ongoing internal bleeding, pulmonary edema, severe anemia.

    Carefully:

    Renal failure, bronchial asthma, allergic rhinitis, angioedema.

    Pregnancy and lactation:During pregnancy and during lactation it is used only on strict indications, when the prospective benefit for the mother exceeds the potential risk to the fetus and the baby.
    Dosing and Administration:

    Before applying the drug, the doctor registers the label data (name of the drug, manufacturer, serial number) in the patient's medical history. A solution of albumin 10% is administered intravenously by drip or jet.

    A single dose of the drug depends on the concentration of the albumin solution, the initial condition and the age of the patient. A solution of albumin 10% is administered at a dose of 200-300 ml. The rate of administration of a 10% solution of albumin is not more than 40 drops per minute. The jet injection of the albumin solution is acceptable for shocks of various genesis for a rapid increase in blood pressure.

    In pediatric practice, the dosage of the albumin solution is calculated taking into account the concentration in milliliters per kilogram of body weight (not more than 3 ml / kg of the body weight of the child).

    In the elderly, rapid administration of a 10% solution of albumin should be avoided, as this can lead to an overload of the cardiovascular system.

    Before starting infusion, the albumin solution should be warmed to room temperature.

    The preparation is not suitable for use in containers with broken integrity of a bottle or ampoule or by marking, with a change in physical properties (color change, cloudiness of solution, presence of suspended matter, sediment), expired shelf life, improper storage.

    Side effects:

    The introduction of a solution of albumin 10%, as a rule, is not accompanied by adverse reactions and complications. Individual, previously sensitized patients, may develop allergic reactions of varying severity. The possibility of occurrence (extremely rare) of reactions and complications is not excluded in patients belonging to the risk group, that is, having a history of intolerance to intravenous infusions of protein preparations and other plasma substitutes, drugs, serums, vaccines. Perhaps it isande hyperthermia, pain in the lumbar region. risk group, i.e.,having in the anamnesis indications on intolerance of intravenous injections of protein preparations and other plasma substitutes, drugs, serums, vaccines. There may be hyperthermia, pain in the lumbar region.

    With rapid intravenous formulation may be a reduction in blood pressure, which is due to the presence of the plasma protein fraction vasoactive compounds (kallikrein activator). When the initial signs of anaphylactic reactions or too rapidly (headache, dyspnea, suffocation) albumin transfusion must stop immediately and without removing the needle from the vein, enter the appropriate drugs (antihistamines, cardiotonic agents, glucocorticoids, pressor agents if indicated).

    Overdose:

    In case of an overdose of the drug, hypervolemia (development of pulmonary edema, increased arterial and central venous pressure) may occur.

    Treatment: symptomatic.

    Special instructions:Introduction with dehydration is possible only after preliminary ensuring sufficient intake of fluid (by mouth, parenterally).
    Form release / dosage:Solution for infusions 10%.
    Packaging:

    Solution for infusions of 10% for 100 and 200 ml in bottles of glass or in ampoules of 20 ml. Each bottle is packed in a pack of cardboard for consumer packaging along with instructions for use. 10 ampoules are packed in a pack of cardboard for consumer packaging along with instructions for use.

    Storage conditions:

    In a dry, dark place at a temperature of 2 to 10 ° C. Keep out of reach of children. Transportation is carried out by any kind of covered transport at a temperature of 2 to 100 FROM.

    Shelf life:5 years. Do not use after expiry date.
    Terms of leave from pharmacies:On prescription
    Registration number:P N003367 / 01
    Date of registration:17.09.2009
    The owner of the registration certificate:IVANOV REGIONAL STATION OF BLOOD TRANSFUSION IVANOV REGIONAL STATION OF BLOOD TRANSFUSION Russia
    Manufacturer: & nbsp
    Information update date: & nbsp29.08.2015
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