Albumin - instructions for use, dose, side effects, contraindications

Plasma-replacing agent obtained by fractionating plasma, serum from healthy donors. Replenishes the deficit of blood plasma albumin, supports the colloid-osmotic (oncotic) blood pressure, rapidly increases blood pressure and BCC, facilitates the passage of fluid from tissues into the bloodstream, and has detoxification properties.Albumin is a natural protein, which is an integral part of the protein fraction of human blood, with a molecular weight of 69,000 daltons. Normally, plasma of human blood albumin is about 60%. The protein albumin molecule contains all 20 amino acids. The synthesis of albumin occurs in the liver. Albumin in the body performs a number of functions. Its main function is the maintenance of colloid-oncotic blood pressure. Albumin solution 100 mg / ml is an effective tool for correcting hypoalbuminemia of various genesis, disturbed central and peripheral hemodynamics, water-electrolyte equilibrium, has detoxification properties. Albumin binds and transports pigments (bilirubin), fatty acids, ions of certain metals, medicinal substances into the body. In addition, albumin binds toxins and inactivates them.

Indications:

Shock (traumatic, operational, toxic); burns accompanied by dehydration and "thickening" of blood; acute hemorrhage; purulent-septic conditions; liver disease (with violation of albumin-synthesizing function); kidney damage (nephritis, nephrotic syndrome).

Hypoproteinemia, hypoalbuminemia of various genesis, developing with alimentary dystrophy, a decrease in albumin in the plasma below 30 g / l, or a level of colloid-oncotic pressure below 15 mm Hg. or, with a decrease in total protein below 50 g / l; damage to the digestive tract with impaired absorption or patency.

In operations with the use of artificial circulation; therapeutic plasmapheresis; hemolytic disease of newborns during an exchange transfusion.

With preoperative hemodilution and preparation of autoblood components; with edema of the brain.

Contraindications:

Increased individual sensitivity, hypervolemia, heart failure IIB-III degree, pulmonary edema, severe anemia.

Carefully:Renal failure, hemorrhage, thrombosis, arterial hypertension.

Pregnancy and lactation:Albumin solution should be used during pregnancy and during breastfeeding only if the potential benefit to the mother exceeds the possible risk to the fetus or child.

Dosing and Administration:

A solution of albumin 10% and 20% intravenously drip at a speed of no more than 40-50 drops per minute, a single dose is determined individually taking into account the age and severity of the patient's condition; solution of albumin 5% - with a speed of no more than 50-60 drops per minute.

In pediatric practice, a solution of albumin 10% is prescribed in a dose of 3 ml / kg of body weight. Older people should avoid the use of concentrated solutions of albumin 20% and rapid administration of solutions of albumin 5 and 10%, as this can lead to an overload of the cardiovascular system.

Bolus albumin solution is permissible shocks of various origins for the rapid increase in blood pressure.

Side effects:

The introduction of albumin solution, as a rule, is not accompanied by adverse reactions and complications. In some previously sensitized patients, allergic reactions of varying severity may occur. The possibility of (extremely rare) occurrence of adverse reactions and complications is not excluded in patients belonging to the risk group, i.e. who have a history of intolerance of intravenous infusions of protein preparations and other plasma substitutes, drugs, serums, vaccines.

In case of reactions or complications, the transfusion of the albumin solution should be stopped immediately and, without removing the needle from the vein, administer antihistamines, cardiotonic drugs, glucocorticosteroids, vasopressor preparations (if there are indications).

Overdose:Cases of overdose are not described.

Interaction:To infuse the albumin solution, use a separate system. In cases of large blood loss, the use of albumin solution can be combined with blood transfusion.

Special instructions:

Before use, it is necessary to make a visual inspection of the preparation and packaging: the solution must be transparent, not containing any inclusions, the glass packaging must be hermetic, without cracks. In the case history, it is necessary to register the label data (name of the preparation, manufacturer, serial number).

Administration of the drug during dehydration is possible only after preliminary ensuring sufficient fluid intake (inside and parenterally).

Data on the use of albumin during lactation are absent.

When using drugs prepared from human plasma, it is impossible to completely eliminate the risk of transmission of known and as yet unknown virus infections.

Caution is prescribed for oppression of heart function (due to the possible occurrence of acute heart failure).

Effect on the ability to drive transp. cf. and fur:Data on the effect of the drug on the ability to drive vehicles, mechanisms are absent.

Form release / dosage:Solution for infusions 5%, 10%, 20%.

Packaging:Solution for infusions 5%, 10%, 20% for 50, 100, 200 and 400 ml in glass bottles (bottles) for blood, transfusion and infusion preparations. For 1 bottle (vial) in a pack of cardboard along with instructions for use.

Storage conditions:In a place protected from light and inaccessible to children at a temperature of 2 to 10 ° C.

Shelf life:5 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-002333

Date of registration:19.01.2012

The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia

Manufacturer: & nbsp

MICROGEN FGUP NGO Russia

Information update date: & nbsp28.08.2015

Illustrated instructions

Instructions

Albumen (Albumin)