Active substanceHuman albuminHuman albumin
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  • Dosage form: & nbspsolution for infusions
    Composition:

    Albumin

    50 grams

    100 g

    Sodium caprylate

    1.5 g

    3 grams

    Sodium chloride

    9 grams

    -

    Water for Injection

    up to 1 liter

    up to 1 liter

    Description:Transparent yellow liquid colors, allowed a greenish tinge.
    Pharmacotherapeutic group:Plasmasuberant
    ATX: & nbsp

    B.05.A.A.01   Albumen

    Pharmacodynamics:

    Albumin is a natural protein that is an integral part of the protein fraction of human blood. The molecular weight of albumin is 69,000 daltons. Solutions of albumin 5% and 10% are a means of correcting hypoalbuminemia of various genesis, restoration of colloid-oncotic pressure, impaired central and peripheral hemodynamics, water-electrolyte equilibrium. In conditions of hypovolemia (blood loss), the drug quickly restores blood pressure and the volume of circulating blood.

    Albumin has a detoxification effect. It binds and transports pigments (bilirubin), fatty acids, ions of certain metals, medicinal substances. In addition, albumin binds toxins and inactivates them.

    Indications:

    - Hypoalbuminemia of various genesis (decrease in albumin content in plasma), or a decrease in the level of colloid-oncotic pressure below 15 mm Hg.or with a decrease in the total protein content below 5 g / l;

    - shock hemorrhagic, traumatic, thermal;

    - acute blood loss (decrease in the volume of circulating blood by more than 25-30%);

    - purulent-septic conditions;

    - liver disease (with violation of albumin-synthesizing function);

    - kidney damage (nephritis, nephrotic syndrome);

    - burn disease;

    - operations using the apparatus of artificial circulation;

    - therapeutic plasmapheresis;

    - hemolytic disease of newborns during the exchange blood transfusion;

    - pre-operative hemodilution and preparation of autoblood components;

    - swelling of the brain.

    Contraindications:

    Hypervolaemia, pulmonary edema, uncontrolled arterial hypertension, severe heart failure, cerebral hemorrhage, severe anemia.

    Carefully:With heart failure (the threat of acute heart failure), arterial hypertension, kidney failure, internal bleeding, thrombosis.
    Dosing and Administration:

    Before the introduction of a solution of albumin 5% or 10%, the physician should conduct a visual inspection of the preparation and its containing containers.The drug must be transparent and must not contain particulate matter and sediment capping tightness saved on bottles should be free of cracks. The results of visual inspection and data labels (the name of the drug, the manufacturer, batch number) are recorded in the history of the disease.

    Solutions of albumin 5% and 10% are administered intravenously by drip or jet. A single dose of the drug depends on the concentration of the albumin solution, the initial condition and the age of the patient. 5-10% albumin solutions are administered in a dose of 200-300 ml when necessary dose of 5% of the solution can be increased to 500-800 ml.

    5% albumin solution to be administered at a rate no higher than 50-60 drops per minute, 10% albumin solution at a rate no more than 40 drops per minute.

    For the treatment of cerebral edema, a hyperoncotic 10% albumin solution is used.

    Bolus albumin solution is permissible shocks of various origins for the rapid increase in blood pressure.

    In pediatric practice, taking into account the concentration of albumin solutions, their dosages should be calculated in milliliters per kilogram of body weight (not more than 3 ml / kg of the child's body weight).

    In the elderly, the use of concentrated solutions and rapid administration of a solution of albumin 5-10% should be avoided,as this can lead to an overload of the cardiovascular system.

    Side effects:

    Administration of a solution of albumin 5% and 10%, as a rule, is not accompanied by adverse reactions and complications. In some previously sensitized patients, allergic reactions of varying severity may occur.

    The possibility of occurrence (extremely rare) of reactions and complications is not excluded in patients belonging to the risk group, i.e. having in the anamnesis indications on intolerance of intravenous injections of protein preparations and other plasma substitutes, drugs, serums, vaccines. In the event of reactions or complications, the administration of the albumin solution should be stopped immediately and, if necessary, without removing the needles from the vein, to carry out the necessary medical measures in accordance with the picture of developing complications.

    Interaction:

    Binding of various drugs (salicylates, sulfamides, barbiturates, penicillin, phenylbutazone) with albumin is usually quite weak, but cases of strong binding, for example, with phenylbutazone, are known. Binding of drugs with albumin leads to the fact that only part of the administered dose gives immediate effect.When administered with the preventive and curative purpose of certain drugs (sulfonamides, antibiotics, etc.) in newborns, the possibility of hemolytic jaundice increases 6 times, since these substances actively displace bilirubin from the binding zones with albumin.

    Special instructions:

    Introduction with dehydration is possible only after preliminary ensuring sufficient intake of fluid (by mouth, parenterally).

    In the case of freezing during transport, the preparation can be used, if during thawing the solution did not change the appearance.

    Form release / dosage:

    Solution for infusions 5%, 10%.

    Packaging:

    For a 10% solution of 100 and 200 ml in blood bottles and 10 and 20 ml in ampoules; for a 5% solution of 200 and 400 ml in bottles for blood.

    Storage conditions:

    At a temperature of 2 to 10 ° C, out of the reach of children.

    Shelf life:5 years. Do not use after the expiry date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:P N002860 / 01
    Date of registration:21.05.2009 / 15.05.2013
    Expiration Date:Unlimited
    The owner of the registration certificate:TYUMENS REGION OF TRANSFUSION OF BLOOD TYUMENS REGION OF TRANSFUSION OF BLOOD Russia
    Manufacturer: & nbsp
    Information update date: & nbsp15.07.2017
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