Albumin - instructions for use, dose, side effects, contraindications

Composition:Composition (per 1 liter of preparation):

Albumin 200 g
sodium caprylate (sodium caprylic acid) 6 g
Sodium Chloride 6 g
water for injection up to 1 liter

Description:Transparent liquid is yellow, a greenish shade is allowed.

Pharmacotherapeutic group:Plasmasuberant

ATX: & nbsp

B.05.A.A.01 Albumen

Pharmacodynamics:

Albumin is an integral part of the protein fraction of human blood. The drug is made from a donor plasma, tested for the absence of antibodies to the human immunodeficiency virus (HIV-1, HIV-2), hepatitis C virus and the surface antigen of the hepatitis B virus.

Albumin in the body performs the following main functions: hemodynamic (maintenance of colloid-oncotic blood pressure), sorption and transport and the function of the main protein reserve of the body.

A 20% albumin solution is a hyperoncotic injection solution. With intravenous injection of 200 ml of 20% solution, the volume of circulating plasma increases by almost 700 ml. This effect is manifested by the attraction of fluid from the interstitial space. Therefore, transfusion of 20% solution must be combined with any other solution (eg, physiological, saline or 5% glucose solution).Albumin binds and inactivates toxins, transports inside the body pigments (bilirubin), fatty acids, ions of certain metals, medicinal substances; improves tissue perfusion in diseases accompanied by hypoproteinemia, has a positive effect on protein-synthesizing function of the liver.

Indications:

The drug is used only for the doctor's prescription with a decrease in albumin in the plasma below 30 g / l, or with a decrease in the total protein content below 50 g / l.

1. Hypoalbuminemia of different genesis:

- shock hemorrhagic, traumatic, thermal;

- acute blood loss (decrease in the volume of circulating blood by more than 25 - 39%);

- purulent-septic conditions;

- liver disease (with violation of albumin-synthesizing function);

- kidney disease (nephritis, nephrotic syndrome);

- burn disease.

2. Operations using artificial circulation.

3. Medical plasmapheresis.

4. Hemolytic disease of newborns during the exchange blood transfusion.

5. Conducting pre-operative hemodilution and preparing components of autoblood.

6. Edema of the brain.

Contraindications:

Hypersensitivity, severe heart failure (due to the possible emergence of acute heart failure), thrombosis, severe form of arterial hypertension, ongoing internal bleeding, pulmonary edema, severe anemia.

Carefully:Renal failure, bronchial asthma, allergic rhinitis, Quincke's edema.

Dosing and Administration:

Before applying the drug, the doctor registers these labels (name of the drug, manufacturer, serial number) in the patient's medical history.

A solution of albumin 20 % injected intravenously drip or jet.

A single dose of the drug may be limited to 100 ml.

The rate of administration of a 20% solution of albumin is not more than 40 drops per minute. The jet injection of albumin solutions is acceptable for shocks of different genesis for rapid increase in blood pressure.

In pediatric practice, the dosage of albumin solutions is calculated taking into account the concentration in milliliters per kilogram of body weight (not more than 3 ml / kg body weight of the child).

In the elderly, rapid introduction of 20 % solutions of albumin, since this can lead to an overload of the cardiovascular system.

Before starting infusion, solutions of albumin should be warmed to room temperature.

Side effects:

The introduction of a 20% albumin solution, as a rule, is not accompanied by adverse reactions and complications. Individual, previously sensitized patients, may develop allergic reactions of varying severity. The possibility of occurrence (extremely rare) of reactions and complications is not excluded in patients belonging to the risk group, that is, having a history of intolerance to intravenous infusions of protein preparations and other plasma substitutes, drugs, serums, vaccines.

With the rapid intravenous administration of the drug, a decrease in blood pressure can be observed, which is due to the presence in the protein plasma fraction of vasoactive compounds (kallikrein activator).

Overdose:

When an overdose or too rapid introduction of the drug may occur phenomena of hypervolemia (development of pulmonary edema, increased arterial and central venous pressure).

With initial signs of an anaphylactic reaction or signs of an overdose (headache, dyspnea, asthma), transfusion of albumin should be stopped immediately and, without removing the needles from the vein,introduce appropriate drugs (antihistamines, cardiotonic drugs, glucocorticoids, vasopressor preparations in the presence of indications).

Form release / dosage:Solution for infusions 20%.

Packaging:

The preparation is produced in the form of 20 % solution for infusions in ampoules of 10, 20 ml or in glass bottles of 50, 100 ml. Each bottle or 5 or 10 ampoules, together with the instruction for use, is placed in a carton box box.

Storage conditions:

In dry, protected from light and out of reach of children at a temperature of 2 to 10 ⁰ C. Transporting is carried out by any kind of indoor transporter at a temperature of 2 to 10 ⁰ FROM.

Shelf life:5 years. Do not use after the time specified on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-001951/09

Date of registration:16.03.2009

The owner of the registration certificate:IVANOV REGIONAL STATION OF BLOOD TRANSFUSION IVANOV REGIONAL STATION OF BLOOD TRANSFUSION Russia

Manufacturer: & nbsp

IVANOV REGIONAL STATION OF BLOOD TRANSFUSION Russia

Information update date: & nbsp29.08.2015

Illustrated instructions

Instructions

Albumen (Albumin)