Doses and mode of administration are set individually, taking into account the nature of the disease and the age of the patient. The average daily dose of Plazbumin 20 for adults is 50 to 75 g; for children - 25 g. The total dose of the drug should not exceed the normal level of albumin (about 2 g / kg body weight) in the absence of active bleeding.
Plasbumin 20 should be administered only intravenously!
Therapy of burns
As a rule, Plasbumin 20 is recommended to be used to maintain the colloidal osmotic pressure of the plasma 24 hours after the thermal damage (in the first day large volumes of saline solutions are poured to restore a reduced volume of extracellular fluid).It is recommended to maintain a concentration of plasma albumin at a level of 20-30 g / l with an oncotic plasma pressure equal to 20 mmHg (equivalent to a total protein concentration of 52 g / L). The duration of therapy is determined by the loss of protein from the burned areas and with urine.
Hypoproteinemia with or without edema of tissues
The usual daily dose of Plasbumin 20 for adults is 50 to 75 g; for children - 25 g. Patients with severe hypoproteinemia who continue to lose albumin may require large quantities. Since patients with hypoproteinemia usually have a normal blood volume, the infusion rate of Plasbumin 20 should not exceed 2 ml / min, as a more rapid administration can cause circulatory disorders and pulmonary edema.
Acute Respiratory Distress Syndrome Adult (ARDS)
If patients have clinical signs indicating simultaneously hypoproteinemia and hypervolemia, it is advisable to designate Plasbumin 20 in the above doses together with a diuretic.
Aorto / coronary bypass
The common practice of hemodilution therapy (to fill the APC during surgery) is the use of albumin and crystalloids until the patient achieves a hematocrit 20% and a plasma albumin concentration of 25 g / l.
Hemolytic disease of newborns
Plazbumin 20 is prescribed approximately one hour before the beginning of the procedure of exchange transfusion in a dose of 1 g / kg of body weight. Care must be taken in the presence of initial hypervolemia in children.
Transfusion of erythrocyte mass
Usually Plasbumin 20 is added to an isotonic suspension of washed red blood cells in a dose of 25 g albumin per 1 liter of erythrocyte mass just before the transfusion of thawed washed out red blood cells. If the patient has concomitant hypoproteinemia or severe liver damage, the dose of Plazbumin 20 can be increased.
Acute nephritis
To increase the effectiveness of therapy with cyclophosphamide or steroids, as well as with the onset of edematous syndrome against the background of steroids, 100 ml of Plasbumin 20 and loop diuretics can be administered daily for 7-10 days under the control of diuresis and potassium concentration in the blood plasma.
Hemodialysis
Introduction Plasbumin 20 is indicated in the development of shock or hypotension in patients with chronic renal failure during routine hemodialysis. The standard dose is 100 ml of Plasbumin 20.It is necessary to avoid overload with the volume often observed in such patients (which is why they can not tolerate the introduction of large volumes of saline solutions).