Intravenous drip or stream. A single dose of the drug depends on the concentration of the albumin solution, the initial condition and the age of the patient. Solutions of albumin 5-10% are administered in a dose of 200-300 ml, if necessary, a dose of 5% solution can be increased to 500-800 ml.
A solution of albumin 5% is administered at a rate of not more than 50-60 drops per minute. A single dose of 20% albumin is 100 ml. Solutions of albumin 10-20% are injected at a speed of not more than 40 drops per minute. Correction of the rate of 5-20% albumin is carried out depending on the patient's hemodynamic response. It is possible to inject albumin solutions in a shock of various genesis in order to rapidly increase blood pressure. In elderly patients, the use of concentrated (20%) solutions and rapid administration of 5-10% albumin should be avoided, as this can lead to an overload of the cardiovascular system.
Hypovolemia - 25 g of albumin (500 ml of 5% albumin or 100 ml of 25% albumin) is intravenously dripped with the maximum tolerated rate.Repeat if no adequate response occurred within 15-30 minutes.
Hypoproteinemia - 50-75 g of albumin (25% solution) at a rate of 100 ml for 30-40 minutes. For slow infusion, 50 g of albumin in 300 ml of 10% glucose at a rate of 100 ml / h.
Burns - therapy begins with the introduction of large volumes of crystalloids that support the volume of plasma. After 24 hours, albumin can be added in an initial dose of 25 g, and then the dose is ditched to maintain a concentration of albumin in the plasma of 25 g / l or a protein concentration of 52 g / l.
Acute nephrotic syndrome - 25 g of albumin in the form of a 25% solution is administered in combination with diuretics 1 time per day for 7-10 days.
Extracorporeal circulation - 5% or 25% albumin in combination with crystalloids (priming the device before use) to achieve albumin concentration in plasma 25 g / l or hematocrit 20%.
Ascites - to maintain cardiovascular function after laparocentesis and remove large volumes of fluid: 4-8 g of albumin per 1 liter of removed ascites fluid.
Hemodialysis (with long-term hemodialysis and a tendency to shock and hypotension or to treat shock or hypotension in hypervolemic patients who do not tolerate large amounts of crystalloids) - intravenously 25 g of albumin as a 25% solution.
Dilution after transfusion of erythrocyte mass - 20-25 g of albumin in the form of 25% solution per 1 liter of erythrocyte mass.
Treatment plasmapheresis - 5% albumin with a plasma loss of more than 20 ml / kg during one procedure or more than 20 ml / kg per week with multiple plasmapheresis.
Use in children
5% albumin - acute or subacute plasma loss, for example, with burns, pancreatitis, trauma or complications of operations, plasma exchange. Hypovolemia - 2.5-12.5 g or 0.5-1.0 g / kg intravenously drip with the maximum tolerated patient rate. Repeat if there is no adequate response in 15-30 minutes. Burns - begin with the introduction of crystalloids to maintain the volume of plasma. After 24 hours, albumin may be added at an initial dose of 25 g, and then the dose is dispensed to maintain a concentration of albumin of 25 g / l or a protein concentration of 52 g / l.
20% albumin - severe hypoalbuminemia, accompanied by a reduced volume of plasma, generalized edema, when it is necessary to limit the intake of salt and water in the composition of plasma-substituting solutions; as an addition to blood transfusion in the treatment of hyperbilirubinemia in newborns (1 g / kg 1-2 hours before or during an exchange blood transfusion to bind and remove bilirubin).