Human serum albumin - instructions for use, dose, side effects, contraindications

Polypeptide, one of the main protein components of blood serum. Albumin is a natural protein that is an integral part of the protein fraction of human blood. The molecular weight of albumin is 69,000. The synthesis of albumin occurs in the liver.

Pharmacodynamics

Plasma-reducing agent obtained by fractionating human plasma. Replenishes the deficiency of plasma albumin, supports colloid osmotic (oncotic) blood pressure, rapidly increases blood pressure and circulating blood volume,increases the transition and promotes retention of tissue fluid in the bloodstream, increases the reserves of protein nutrition of tissues and organs.

It has detoxification properties.

Indications:

- Shock (traumatic, operational and toxic);

- burns, accompanied by dehydration and blood concentration;

- hypoproteinemia, hypoalbuminemia, developing with alimentary dystrophy, nephrotic syndrome, glomerulonephritis, cirrhosis of the liver for prolonged suppuration;

- lesions of the gastrointestinal tract with impaired feeding of the patient (peptic ulcer of stomach and duodenum, tumors, violation of patency of gastrointestinal anastomosis);

- neonatal hyperbilirubinemia;

- swelling of the brain.

Contraindications:

Hypersensitivity, severe anemia, chronic heart failure IIB - stage III, hypervolemia, pulmonary edema.

Carefully:

Arterial hypertension, renal failure, thrombosis, ongoing internal bleeding, chronic heart failure of stage I.

Pregnancy and lactation:

When pregnancy, the use of albumin is possible only in cases of extreme necessity.Data on the safety of the use of albumin during lactation are absent.

Dosing and Administration:

Intravenously drip. The dose is set individually depending on the indications and the clinical picture.

A solution of albumin 5 % injected at a rate of 50-60 cap / min; single dose for adults 5% solution of albumin - 500 ml, for children - 125 - 250 ml. A solution of albumin 20% is injected at a rate of not more than 40 cap / min; single dose for adults 20% albumin solution - 100 ml.

Side effects:

From the digestive system: nausea, vomiting, hypersalivation are possible.

From the cardiovascular system: lowering of blood pressure, tachycardia.

Allergic reactions: possible hives; rarely anaphylactic shock.

Other: there may be an increase in body temperature, pain in the lumbar region.

In case of reactions or complications, the transfusion of the albumin solution should be stopped immediately and, without removing the needle from the vein, administer antihistamines, cardiotonic drugs, glucocorticosteroids, vasopressor preparations (if there are indications).

Overdose:

Clinical manifestations of overdose may be a hypervolemic symptom complex: increased blood pressure, the appearance or increase of heart failure, etc.

In case of an overdose, discontinue the administration of albumin, carry out symptomatic treatment.

Interaction:

With the simultaneous use of human serum albumin with ACE inhibitors, the risk of developing arterial hypotension increases.

Special instructions:

Patients with dehydration should be ensured sufficient fluid intake before administration of human serum albumin. The solution should be clear and should not contain suspended solids.

The shelf life of the drug after opening the bottle is 4 hours. Unused residues of the drug should be destroyed.

Although selection and screening of blood donors and pasteurization of the drug at a temperature of 60 ° C for 10 hours virtually eliminates the possibility of contracting blood-borne infections, nevertheless, when using drugs from human blood and plasma, the probability of infection with infectious diseases can not be completely ruled out.

Form release / dosage:Solution for infusions 5%, 20%.

Packaging:

Solution for infusions 5%: on 100 ml in a vial from transparent glass of a class 1, Corked with rubber stopper with aluminum rolling and protective plastic lid.1 bottle with a plastic holder and instructions for use in a cardboard box.

Solution for infusions 20%: 50, 100 ml in a vial of transparent glass class 1, ukuporenny rubber stopper with aluminum obakkoy and protective plastic lid. 1 bottle with a plastic holder and instructions for use in a cardboard box.

Storage conditions:

List B. In the dark place at a temperature of no higher than 25 ° C.

Do not freeze.

Shelf life:

3 years.

Do not use after the time specified on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-005339/08

Date of registration:08.07.2008

Expiration Date:Unlimited

The owner of the registration certificate:Green Cross CorporationGreen Cross Corporation The Republic of Korea

Manufacturer: & nbsp

Green Cross Medical Science Corporation The Republic of Korea

Representation: & nbspMEDARGO FK LLCMEDARGO FK LLCRussia

Information update date: & nbsp15.07.2017

Illustrated instructions

Instructions

Human serum albumin (Albumin human serum)