Albumin - instructions for use, dose, side effects, contraindications

Albumin, an infusion solution of 20% obtained from the plasma for fractionation, with the addition of sodium caprylate 0.6 g, sodium chloride up to 160 mmol / l and water for injection up to 100 ml.

Description:Transparent liquid is yellow, a greenish shade is allowed.

Pharmacotherapeutic group:Plasmasuberant

ATX: & nbsp

B.05.A.A.01 Albumen

Pharmacodynamics:

Albumin is a natural protein that is an integral part of the protein fraction of human blood. Polypeptide, one of the main protein components of blood serum. The molecular weight of albumin is 69,000 Da. Normally, human blood plasma for albumin accounts for about 60%. The synthesis of albumin occurs in the liver.

Plasma-replacing agent obtained by fractionating human plasma free from HIV-1, 2, hepatitis C viruses and Hepatitis B surface antigen. Replenishes plasma albumin deficiency, maintains colloid osmotic (oncotic) blood pressure, rapidly increases blood pressure and circulating blood volume, increases transition and promotes retention of tissue fluid in the bloodstream, increases the reserves of protein nutrition of tissues and organs.It has detoxification properties.

Pharmacokinetics:No data available.

Indications:

Decrease in albumin concentration in plasma less than 30 g / L or colloid osmotic (oncotic) pressure less than 15 mm Hg, or decrease in total plasma protein less than 50 g / l:

hypoalbuminemia of various genesis: shock (hemorrhagic, traumatic, thermal), acute blood loss (decrease in the volume of circulating blood by more than 25-30%); purulent-septic conditions; liver disease with violation of albumin-synthesizing function, kidney disease (nephritis, nephrotic syndrome), burn disease;

operations using artificial circulation; therapeutic plasmapheresis;

hemolytic disease of newborns during the exchange blood transfusion;

pre-operative hemodilution and preparation of autoblood components; swelling of the brain.

Contraindications:

Hypersensitivity, severe anemia, chronic heart failure II-III stage, hypervolemia, pulmonary edema.

Carefully:Arterial hypertension, renal failure, thrombosis, ongoing internal bleeding, chronic heart failure of stage I.

Pregnancy and lactation:

During pregnancy or lactation, use for life indications, comparing the benefits to the mother and the risk to the fetus.

Dosing and Administration:

Intravenous drip or jet, at a speed of no more than 40 cap / min. A single dose of 20% solution is 100 ml.

Bolus albumin solution is permissible shocks of various origins for the rapid increase in blood pressure.

The dose is set individually depending on the indications and the clinical picture.

In pediatric practice, the dose of albumin is calculated taking into account the concentration in ml per kg of body weight of the child (not more than 3 ml / kg).

In old age should avoid use of concentrated (20%) solutions and rapid administration of the drug due to the risk overloading the cardiovascular system may use 0.9% sodium chloride solution or 5% dextrose solution as a diluent.

Side effects:

Allergic reactions: urticaria, anaphylactic shock.

Other: hyperthermia, pain in the lumbar region.

Overdose:

At too high a dose or rate of infusion solution injection, hypervolemia can develop.At the first manifestations of symptoms of cardiovascular system overload (headache, dyspnoea, jugular veins overflow) or with increased blood pressure, increased venous pressure, development of pulmonary edema, the infusion should be stopped immediately and the patient's hemodynamic parameters monitored.

Interaction:

Pharmaceutical interaction

Albumin is compatible with whole blood, erythrocyte mass, with standard electrolyte and carbohydrate solutions for intravenous infusions.

Albumin should not be mixed with protein hydrolysates, amino acid solutions and ethanol-containing solutions.

Do not use water for injection as a diluent, as this can lead to acute hemolysis and acute renal failure.

Special instructions:

Introduction with dehydration is possible only after preliminary ensuring sufficient intake of fluid (by mouth, parenterally).

Do not use the product if the appearance changes, if the integrity and integrity of the primary packaging is compromised.

Form release / dosage:Solution for infusions 20%.

Packaging:

Solution for infusions 20% (bottles for blood substitutes) 100 ml.Each bottle in a pack of cardboard along with instructions for use.

Storage conditions:

At a temperature of 2 to 10 ° C. Keep out of the reach of children.

Shelf life:

5 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LP-000332

Date of registration:22.02.2011

The owner of the registration certificate:TAMBOV REGIONAL STATION OF BLOOD TRANSFUSION TAMBOV REGIONAL STATION OF BLOOD TRANSFUSION Russia

Manufacturer: & nbsp

TAMBOV REGIONAL STATION OF BLOOD TRANSFUSION Russia

Information update date: & nbsp29.08.2015

Illustrated instructions

Instructions

Albumen (Albumin)