Albumin - instructions for use, dose, side effects, contraindications

Composition:1 ml of the preparation contains: active substance albumin 50/100/200 mg. Excipients: sodium caprylate 1.5 / 3/6 mg, sodium chloride 9/0/0 mg, water.

Description:Transparent liquid of yellow color. A greenish shade is allowed.

Pharmacotherapeutic group:Plasmasuberant

ATX: & nbsp

B.05.A.A.01 Albumen

Pharmacodynamics:

Albumin is a natural protein that is an integral part of the protein fraction of human blood. The molecular weight of albumin is 69,000 daltons. Solutions of albumin 5, 10, 20% are a means of correcting hypoalbuminemia of different genesis, restoration of colloid-oncotic pressure, impaired central and peripheral hemodynamics, water-electrolyte equilibrium, have detoxification properties.

Albumin binds and transports inside the body pigments (bilirubin), fatty acids, ions of certain metals, medicinal substances. In addition, albumin binds toxins and inactivates them.

Indications:

- Reduction of albumin in the plasma is below 30 g / l, or the level of colloid-oncotic pressure is below 15 mm. gt; or reduction in the total protein content below 50 g / l;

- hypoalbuminemia of different genesis:

- shock (hemorrhagic, traumatic, thermal);

- acute blood loss (decrease in the volume of circulating blood by more than 25-30%);

- purulent-septic conditions;

- liver disease (with violation of albumin-synthesizing function);

- kidney damage (nephritis, nephrotic syndrome);

- burn disease;

- operations using artificial circulation;

- therapeutic plasmapheresis;

- hemolytic disease of newborns during the exchange blood transfusion;

- pre-operative haemodulation and preparation of autoblood components;

- swelling of the brain.

Contraindications:

- Increased individual sensitivity to the drug;

- hypervolemia;

- pulmonary edema;

- uncontrolled arterial hypertension;

- severe heart failure (IIAT-III stage);

- thrombosis;

- cerebral hemorrhage;

- internal bleeding.

Carefully:

Use with caution in heart failure stage I, kidney failure, arterial hypertension.

Pregnancy and lactation:

The use of albumin during pregnancy and lactation is possible only if the potential benefit to the mother exceeds the possible risk to the fetus or child.

Dosing and Administration:

Before transfusion of a solution of albumin 5, 10, 20% the doctor should spend visual inspection of a preparation and containing its capacities. The drug should be visually transparent and should not contain suspended matter and sediment. The drug is considered suitable for use under the condition that the sealing is closed, there are no cracks on the bottles, and the label is safe. The results of visual inspection and data labels (the name of the drug, the manufacturer, batch number) are recorded in the history of the disease.

Solutions of albumin 5, 10, 20% are administered intravenously by drip or jet. A single dose of the drug depends on the concentration of the albumin solution, the initial condition and the age of the patient. Solutions of albumin 5, 10, 20% are administered in a dose of 200-300 ml, if necessary, the dose of 5% solution can be increased to 500-800 ml.

A solution of albumin 5% should be administered at a speed of not more than 50-60 drops per minute. A single dose of 20% albumin can be limited to 100 ml.

Solutions of albumin 10, 20% should be administered at a speed of not more than 40 drops per minute.

For the treatment of cerebral edema, hyperoncotic 10, 20% albumin solutions are used.

Jet injection of albumin solutions is permissible in case of shock of various genesis (hemorrhagic, thermal, traumatic) for rapid increase of arterial pressure.

In pediatric practice, taking into account the concentration of albumin solutions, their dosages should be calculated in milliliters per kilogram of body weight (not more than 3 ml / kg of the child's body weight).

In the elderly, the use of concentrated (20%) solutions and rapid administration of solutions of albumin 5, 10 %, as this can lead to an overload of the cardiovascular system.

Side effects:

In rare cases, it is possible to develop allergic reactions: urticaria, chills, fever, shortness of breath, tachycardia, lowering blood pressure, pain in the lumbar region.

In case of reactions or complications, the administration of the albumin solution should be stopped immediately and, without removing the needles from the vein, administer antihistamines, cardiotonic drugs, glucocorticoids, vasopressor preparations (if there are indications).

Interaction:

Simultaneous use of albumin solution with salicylates, sulfonamides, barbiturates, penicillins, phenylbutazone leads to a weakening of the therapeutic effect of albumin.

Do not mix albumin with protein hydrolysates, amino acid solutions and alcohol-containing preparations.

Special instructions:

Introduction during dehydration is possible only after preliminary ensuring sufficient fluid intake (inside and parenteral).

In the case of freezing during transport, the preparation can be used if the solution does not change the appearance when thawing.

With the introduction of the drug, infection with blood-borne infections is possible.

Form release / dosage:Solution for infusions 5%, 10%, 20%.

Packaging:

A solution for infusions of 20% to 50 and 100 ml, a solution for infusions of 5% and 10% of 50,100, 200 and 400 ml into glass bottles with a capacity of 50, 100, 250 and 500 ml respectively. Solution for infusions 5%, 10%, 20% for 10 and 20 ml in ampoules glass.

The bottles are hermetically sealed with rubber stoppers and crimped with aluminum caps.

Each bottle or ampoules of 10 pcs. together with the instructions for use are placed in a pack of cardboard box. In a pack of ampoules, an ampoule knife is inserted. In the event that the ampoules have a colored ring of fracture, an incision, an identification color point on the vial of an ampoule, an ampoule knife is not put into a pack of cardboard.

Storage conditions:

At temperatures from +2 ° C to +10 ° C, out of the reach of children.

Shelf life:

5 years.Do not use after the time specified on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N001819 / 01

Date of registration:29.08.2008 / 11.09.2012

Expiration Date:Unlimited

The owner of the registration certificate:SVERDLOVSK REGIONAL STATION OF BLOOD TRANSFUSION OF GBUZ SOSVERDLOVSK REGIONAL STATION OF BLOOD TRANSFUSION OF GBUZ SO Russia

Manufacturer: & nbsp

SVERDLOVSK REGIONAL STATION OF BLOOD TRANSFUSION OF GBUZ SO Russia

Information update date: & nbsp15.07.2017

Illustrated instructions

Instructions

Albumen (Albumin)