The incidence of adverse events is classified according to WHO recommendations: very often - not less than 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01%; The unknown frequency can not be estimated from the available data.
Infectious diseases:
infrequently: candidiasis, including mucous membranes of the mouth and genitals, pneumonia, pharyngitis, gastroenteritis, respiratory diseases, rhinitis;
unknown frequency: pseudomembranous colitis.
On the part of the blood and lymphatic system:
infrequently: leukopenia, neutropenia, eosinophilia;
very rarely: thrombocytopenia, hemolytic anemia.
From the side of metabolism and nutrition:
infrequently: anorexia.
Allergic reactions:
infrequently: angioedema, hypersensitivity reaction;
unknown frequency: anaphylactic reaction.
From the nervous system:
often: headache;
infrequently: dizziness, dyspnoea, paresthesia, drowsiness, insomnia, nervousness;
rarely: agitation;
unknown frequency: hypesthesia, anxiety, aggression, fainting, convulsions, psychomotor hyperactivity, loss of smell, perversion of smell, loss of taste sensations, myasthenia gravis, delirium, hallucinations.
From the side of the organ of vision:
often: impaired vision.
From the side of the hearing organ and labyrinthine disorders:
infrequently: hearing disorder, vertigo;
unknown frequency: hearing impairment, including deafness and / or tinnitus.
From the side of the cardiovascular system:
infrequent: a feeling of palpitations, "tides" of blood to the skin of the face;
unknown frequency: lowering blood pressure, lengthening the interval QT on the electrocardiogram, arrhythmia of the type "pirouette", ventricular tachycardia.
From the respiratory system:
infrequently: shortness of breath, nosebleed.
From the digestive system:
very often: diarrhea;
often: nausea, vomiting, abdominal pain;
infrequent: flatulence, dyspepsia, constipation, gastritis, dysphagia, bloating, dryness of the oral mucosa, belching, ulcers of the oral mucosa, increased secretion of the salivary glands;
very rarely: discoloration of the tongue, pancreatitis.
From the liver and biliary tract:
infrequently: hepatitis;
rarely: a violation of the liver, cholestatic jaundice;
unknown frequency: hepatic insufficiency (in rare cases with a fatal outcome, mainly on the background of a severe liver function disorder), liver necrosis, fulminant hepatitis.
From the skin and subcutaneous tissues:
infrequently: skin rash, itchy skin, hives, dermatitis, dry skin, increased sweating;
rarely: the reaction of photosensitization;
unknown frequency: Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme.
From the side of the musculoskeletal system:
infrequently: osteoarthritis, myalgia, back pain, neck pain;
unknown frequency: arthralgia.
From the side of the kidneys and urinary tract:
infrequently: dysuria, pain in the kidney area;
unknown frequency: interstitial nephritis,acute renal failure.
From the genitals and breast:
infrequently: metrorrhagia, dysfunction of testicles.
Other:
infrequently: asthenia, malaise, fatigue, face swelling, chest pain, fever, peripheral edema.
Laboratory data:
often: a decrease in the number of lymphocytes, an increase in the number of eosinophils, an increase in the number of basophils, an increase in the number of monocytes, an increase in the number of neutrophils, a decrease in the concentration of bicarbonates in the blood plasma;
infrequently: increased activity of aspartate aminotransferase, alanine aminotransferase, increased bilirubin concentration in blood plasma, increased urea concentration in blood plasma, increased plasma creatinine concentration, changes in potassium content in blood plasma, increased activity of alkaline phosphatase in blood plasma, increased levels of chlorine in blood plasma , increased blood glucose, increased platelet count, increased hematocrit, increased bicarbonate concentration in blood plasma, a change in the content sodium in the blood plasma.