The incidence of side effects is classified according to the recommendations of the World Health Organization: very often - not less than 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01% (including isolated cases).
Infectious diseases:
infrequently - Candidiasis, including the mucous membrane of the mouth and genitals;
rarely - pseudomembranous colitis.
From the side of metabolism and nutrition: often anorexia.
Allergic reactions:
often - skin itching, skin rash;
infrequently - hypersensitivity reactions, photosensitization reaction, urticaria, Stevens-Johnson syndrome, angioedema;
rarely - Anaphylactic reaction, erythema multiforme, toxic epidermal necrolysis.
From the side of blood and lymphatic system:
often - eosinophilia, lymphopenia;
infrequently - leukopenia, neutropenia;
rarely - thrombocytopenia, hemolytic anemia.
From the respiratory system:
infrequently - pneumonia, pharyngitis, respiratory diseases, rhinitis, shortness of breath, nosebleeds.
From the nervous system:
often - headache, dizziness, paresthesia, a violation of taste; infrequently - hypoesthesia, drowsiness, insomnia, nervousness;
rarely - agitation;
rarely - anxiety, aggression, fainting, convulsions, psychomotor hyperactivity, loss of smell (or anosmia) and taste sensations, myasthenia gravis, anxiety;
frequency unknown - perversion of smell, delirium, hallucinations.
From the side of the organ of vision: often - impaired vision.
From the side of the hearing organ and labyrinthine disorders:
often - deafness;
infrequently - Tinnitus, hearing disorder;
rarely - Vertigo.
From the cardiovascular system:
infrequently - sensation of the heartbeat, "tides" of blood to the skin of the face;
rarely - lowering blood pressure, increasing the interval QT, arrhythmia such as "pirouette", ventricular tachycardia.
From the gastrointestinal tract:
Often - nausea, flatulence, abdominal pain, diarrhea;
often - dyspepsia, vomiting;
infrequently - constipation, gastritis, gastroenteritis, dysphagia, bloating, dryness of the oral mucosa, belching, ulcers of the oral mucosa, increased secretion of the salivary glands;
rarely - changing the color of the tongue, pancreatitis.
From the liver and bile ducts:
infrequently - increased activity of "hepatic" transaminases, increased concentration bilirubin, hepatitis;
rarely - abnormal liver function;
rarely - cholestatic jaundice, hepatic insufficiency (in rare cases with a fatal outcome mainly on the background of severe violations of the liver function), liver necrosis, fulminant hepatitis.
From the skin:
infrequently - dermatitis, dry skin, increased sweating.
From the osteomuscular system and connective tissue:
often - arthralgia;
infrequently - osteoarthritis, myalgia, back pain, neck pain.
From the genitourinary system:
infrequently - an increase in the concentration of urea and creatinine in the blood plasma, dysuria, pain in the kidney, metrorrhagia, dysfunction of the testicles;
rarely - interstitial nephritis, acute renal failure. Laboratory indicators:
often - a decrease in the concentration of bicarbonates in the blood plasma, an increase in the number of: basophils, monocytes, neutrophils;
infrequently - increase in the number of platelets, increase in hematocrit; an increase in the activity of alkaline phosphatase, an increase in the chlorine content, an increase in the concentration of glucose in the blood plasma, an increase in the concentration of bicarbonates in the blood plasma, a change in the sodium content in the blood plasma, a change in the potassium concentration.
Other:
often - weakness;
infrequently - chest pain, peripheral edema, asthenia, malaise, fatigue, face swelling, fever.