Most of the reported adverse reactions are reversible after the end of the course of treatment or discontinuation of the drug.
Classification of the incidence of adverse events (WHO): very often (with a frequency of more than 1/10), often (with a frequency of at least 1/100 but less than 1/10), infrequently (at a frequency of at least 1/1000 but less than 1 / 100), rarely (with frequency is not less than 1/10000, but less than 1/1000), very rarely (with a frequency of less than 1/10 000), including individual messages.
From the blood and lymphatic systems: often - lymphocytopenia, eosinophilia; infrequently - leukopenia, neutropenia; rarely - thrombocytopenia, hemolytic anemia.
From the central nervous system: often - dizziness, headache, paresthesia, impaired perception of taste, anorexia; infrequently - anxiety, nervousness, hyposthenia, insomnia, drowsiness; rarely - agitation, delirium, hallucinations; very rarely - fainting, convulsions, psychomotor hyperactivity, aggression, anosmia, loss of taste sensations, parosmia, myasthenia gravis exacerbation, perversion of smell.
From the sense organs: infrequently - hearing disorders, vertigo, impaired vision; unknown frequency - hearing impairment, including deafness and / or tinnitus.
From the respiratory system and JIOP- bodies: infrequently - shortness of breath, nosebleed.
From the cardiovascular system: infrequently - a feeling of palpitations, "tides" of blood to the face; very rarely - lowering blood pressure, arrhythmia, ventricular tachycardia, increasing the interval QT, arrhythmia of the "pirouette" type.
Infectious diseases: infrequently - rhinitis, respiratory diseases, pharyngitis, pneumonia, candidiasis, including mucous membranes of the oral cavity and genitals, gastroenteritis.
From the digestive system: very often - nausea, diarrhea, abdominal pain, flatulence (bloating), often - vomiting; infrequent - eructations, dysphagia, gastritis, constipation, dryness of the oral mucosa, ulcers of the oral mucosa, increased secretion of the salivary glands; very rarely - a discoloration of the tongue, pseudomembranous colitis, pancreatitis.
From the liver and bile ducts: infrequently - hepatitis, hyperbilirubinemia, increased activity of "liver" transaminases; very rarely - cholestatic jaundice, hepatic insufficiency (in rare cases, fatal, mainly on the background of a violation of liver function), fulminant hepatitis, liver necrosis.
Allergic reactions: often - itching, rash; infrequently - Stevens-Johnson syndrome, photosensitivity,hives; rarely anaphylactic reactions (including angioedema) in rare cases with fatal outcome, toxic epidermal necrolysis. erythema multiforme.
From the skin and subcutaneous tissues: dry skin, dermatitis, sweating.
From the musculoskeletal system: often - arthralgia; infrequently - osteoarthritis, myalgia, pain in the neck, back pain.
From the genitourinary system: infrequently - increased residual urea nitrogen and creatinine concentration in the blood plasma, dysuria, pain in the kidney, metrorrhagia. dysfunction of testicles; very rarely - interstitial nephritis, acute renal failure.
Other: often - weakness; infrequently - chest pain, peripheral edema, asthenia (malaise, fatigue sensation); infrequently - swelling of the face, fever.
Laboratory data: often - an increase in the number of basophils, monocytes, neutrophils, a decrease in the concentration of bicarbonates in the blood plasma; infrequently, an increase in the activity of alkaline phosphatase, an increase in the chlorine content, an increase in the glucose concentration, an increase in the concentration of bicarbonates in the blood plasma, an increase in the number of platelets, an increase in hematocrit, a change in the sodium content in the blood plasma, and a change in the potassium concentration in the blood plasma.
The occurrence of any side effect should be reported to the doctor in charge.