Most of the reported adverse reactions are reversible after the end of the course of treatment or discontinuation of the drug.
Classification of the incidence of adverse events (WHO): very often (with a frequency of more than 1/10), often (with a frequency of at least 1/100, but less than 1/10), infrequently (at a frequency of at least 1/1000, but less than 1 / 100), rarely (with a frequency of at least 1/10000, but less than 1/1000), very rarely (with a frequency of less than 1/10000), (including individual messages).
From the side of the circulatory and lymphatic systems: often - lymphocytopenia, eosinophilia; infrequently - leukopenia, neutropenia; very rarely - thrombocytopenia, hemolytic anemia.
From the side of the central nervous system: often - dizziness, headache, paresthesia, a violation of perception of taste sensations; infrequently - anxiety, nervousness, hyposthenia, insomnia, drowsiness; rarely - agitation; very rarely - fainting, convulsions, psychomotor hyperactivity, anosmia, loss of taste, parosmia, exacerbation myasthenia gravis.
From the sense organs: infrequent - a decrease in the severity of hearing, tinnitus; rarely - Vertigo, reduced visual acuity, deafness.
From the cardiovascular system: infrequent - a feeling of heartbeat; rarely - lowering blood pressure; very rare - arrhythmia, including: ventricular tachycardia, increased interval Q-T, arrhythmia such as "pirouette."
From the digestive system: very often - nausea, diarrhea, abdominal pain, flatulence; often - vomiting; infrequently - gastritis, constipation, melena, anorexia; very rarely - a discoloration of the tongue, pseudomembranous colitis, pancreatitis.
From the liver and bile ducts: infrequently - hepatitis, hyperbilirubinemia, increased activity of "liver" transaminases; very rarely - cholestatic jaundice, liver failure (in rare cases with a fatal outcome, mainly on the background of a violation of liver function), fulminant hepatitis, liver necrosis.
Allergic reactions: often - itching, rash; infrequently - Stevens-Johnson syndrome, photosensitivity, urticaria; very rarely - anaphylactic reactions (including angioedema) in rare cases with fatal outcome, toxic epidermal necrolysis, erythema multiforme.
From the musculoskeletal system:: often - arthralgia.
From the genitourinary system: infrequent increase of residual urea nitrogen and creatinine concentration in blood plasma; very rarely - interstitial nephritis, acute renal failure.
Other: often - weakness; infrequently - pain in the chest, peripheral edema, asthenia, hyperglycemia, conjunctivitis.
Infections and infestations: infrequently - vaginitis, candidiasis of various localizations.
The occurrence of any side effect should be reported to the doctor in charge.