Classification of adverse reactions according to the frequency of development:
very often - not less than 10%,
often - not less than 1%, but less than 10%,
infrequently - not less than 0.1%, but less than 1%,
rarely - not less than 0.01%, but less than 0.1%,
very rarely - less than 0.01%,
The unknown frequency can not be estimated from the available data.
Infectious diseases: infrequently, candidiasis, including the oral and genital mucosa, pneumonia, pharyngitis, gastroenteritis, respiratory diseases, rhinitis. An unknown frequency is pseudomembranous colitis.
From the side of metabolism and nutrition: often - anorexia.
Allergic reactions: often - itchy skin, skin rash; infrequently - hypersensitivity reaction, photosensitization reaction, urticaria, Stevens-Johnson syndrome, angioedema, dermatitis, dry skin, sweating; very rarely - anaphylactic reaction, erythema multiforme, toxic epidermal necrolysis.
From the blood and lymphatic systems: often - eosinophilia, lymphopenia, basophilia, monocytosis, an increase in the number of neutrophils; infrequently - leukopenia, neutropenia; very rarely - thrombocytopenia, hemolytic anemia.
From the central nervous system: often - headache, dizziness, paresthesia, a violation of taste sensations; infrequently - nervousness, hypoesthesia, drowsiness, insomnia; rarely - agitation; very rarely - anxiety, aggression, fainting, convulsions, psychomotor hyperactivity, disorders, perversion and loss of sense of smell, loss of taste, myasthenia gravis, delirium, hallucinations.
From the side of the organ of vision: often - a violation of the clarity of visual perception.
From the side of the hearing organ and labyrinthine disorders: infrequently - hearing disorder, vertigo; unknown frequency - hearing impairment, including deafness, tinnitus.
From the cardiovascular system: infrequently - a feeling of palpitations, "tides" of blood to the face; unknown frequency - lowering blood pressure, increasing the interval QT, arrhythmia such as "pirouette", ventricular tachycardia.
From the respiratory system: infrequently - shortness of breath, nosebleed.
From the gastrointestinal tract: very often - nausea, flatulence, abdominal pain, diarrhea; often - indigestion, vomiting; infrequent - constipation, gastritis, dysphagia, bloating, dryness of the oral mucosa, belching, ulcers of the oral mucosa, increased secretion of the salivary glands; very rarely - a discoloration of the tongue, pancreatitis.
From the liver and bile ducts: infrequently - hepatitis; rarely - a violation of liver function; very rarely - cholestatic jaundice, hepatic insufficiency (in rare cases with a fatal outcome mainly on the background of severe impairment of liver function), liver necrosis, fulminant hepatitis.
From the osteomuscular system and connective tissue: infrequently - osteoarthritis, myalgia, back pain, neck pain; unknown frequency - arthralgia.
From the side of the kidneys and urinary tract: infrequently - dysuria, pain in the kidney; unknown frequency - interstitial nephritis, acute renal failure.
From the genitals and mammary glands: infrequently - metrorrhagia, dysfunctions of testicles.
Laboratory indicators: often - a decrease in the concentration of bicarbonates in the blood plasma; Infrequent - increased activity "liver" enzymes, increasing the concentration of bilirubin in blood plasma, increasing the concentration of urea and creatinine in blood plasma, a change in the potassium concentration in the blood plasma, increased alkaline phosphatase activity, increasing the concentration of chlorine and plasma glucose, the increase in the platelet count, increased hematocrit, increased concentrations of bicarbonates and changes in the concentration of sodium in the blood plasma.
Other: infrequently - asthenia, malaise, fatigue, face swelling, chest pain, peripheral edema, fever.