The incidence of adverse events is classified according to WHO recommendations. very often - not less than 10%; often - not less than 1%. but less than 10%; infrequently - not less than 0.1%, but less than I%; rarely - not less than 0.01%. but less than 0.1%, very rarely - less than 0.01%; The unknown frequency can not be estimated from the available data.
Infectious diseases: infrequently - candidiasis, including mucous membranes of the mouth and genitals, pneumonia, pharyngitis, gastroenteritis, respiratory diseases, rhinitis; an unknown frequency is pseudomembranous colitis.
From the side of the blood and lymphatic system: infrequently - leukopenia, neutropenia, eosinophilia; very rarely - thrombocytopenia, hemolytic anemia.
From the side of metabolism and nutrition: infrequently - anorexia.
Allergic reactions: infrequently - angioedema, reaction hypersensitivity, unknown frequency - anaphylactic reaction.
From the nervous system: often - headache: rare - dizziness, paraesthesia, taste disturbance, nose running, insomnia, nervousness seldom - agitation: unknown frequency - hypoesthesia. anxiety, aggression, fainting, seizures, psychomotor hyperactivity, loss of smell, sense of smell distortion, loss of taste, myasthenia gravis, delusions, hallucinations
From the side of the organ of vision: infrequent - impaired vision
From the side of the hearing organ and labyrinthine disorders: infrequently - hearing disorder, vertigo; unknown frequency - hearing impairment, including deafness and / or "noise" in the ears
From the cardiovascular system: infrequently - a feeling of palpitations, "tides" of blood to the face; unknown frequency - lowering blood pressure, increasing the interval QT on the electrocardiogram, arrhythmia of the type "pirouette", ventricular tachycardia.
From the respiratory system: infrequently - shortness of breath, nosebleed.
From the gastrointestinal tract: very often diarrhea; hour - nausea, vomiting, abdominal pain, infrequent - meteorism, dyspepsia, gastritis, constipation, dysphagia, bloating, dryness of the oral mucosa, belching, ulcers of the oral mucosa. increased secretion of salivary glands; very rarely - discoloration of the tongue, pancreatitis
From the liver and bile ducts: infrequently - hepatitis; rarely - a violation of liver function, cholestatic jaundice: unknown frequency - hepatic insufficiency (in rare cases with a fatal outcome mainly against a background of severe impairment of liver function), liver necrosis, fulminant hepatitis.
From the skin and subcutaneous tissues: infrequent - skin rash, itching, hives, dermatitis, dry skin, sweating, rarely - photosensitivity reaction, unknown frequency - Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme.
From the musculoskeletal system: infrequently - osteoarthritis, myalgia, back pain, neck pain; unknown frequency - arthralgia
From the side of the kidneys and urinary tract: infrequently - dysuria, pain in the kidney, unknown frequency - interstitial nephritis, acute renal failure.
From the genitals and the breast: infrequently metrorrhagia. dysfunction of the testes
Other: infrequently - asthenia, malaise, fatigue, face swelling, pain and chest, fever, peripheral edema.
Laboratory summer cottage: often a decrease in the number of lymphocytes, an increase in the number of eosinophils, an increase in the number of basophils, an increase in the number of monocytes, an increase in the number of neutrophils, a decrease or increase in the concentration of bicarbonates in the blood plasma; infrequently - increased activity aspartate aminotransferase, alanine aminotransferase, increased bilirubin concentration in the blood plasma,an increase in the concentration of urea in the blood plasma, an increase in the concentration of creatinine in the blood plasma, a change in the potassium content in the blood plasma, an increase in the activity of alkaline phosphatase in the blood plasma, an increase in the level of chlorine in the blood plasma, an increase in the concentration of glucose in the blood, an increase in the number of platelets, increase in hematocrit, sodium content in blood plasma.