Most of the reported adverse reactions are reversible after the end of the course of treatment or discontinuation of the drug.
Classification of the incidence of adverse events (WHO): very often (with a frequency of more than 1/10), often (with a frequency of at least 1/100, but less than 1/10), infrequently (at a frequency of at least 1/1000, but less than 1 / 100), rarely (with a frequency of at least 1/10000, but less than 1/1000), very rarely (with a frequency of less than 1/10000), (including individual messages).
From the blood and lymphatic systems: often - lymphocytopenia, eosinophilia; infrequently - leukopenia, neutropenia; very rarely - thrombocytopenia, hemolytic anemia.
From the side of the central nervous system: often - dizziness, headache, paresthesia, a violation of the perception of taste; infrequently - anxiety, nervousness, hyposthenia, insomnia, drowsiness; rarely - agitation; very rarely - fainting, cramps,psychomotor hyperactivity, anosmia, loss of taste sensations, parosmia, exacerbation of myasthenia gravis.
From the senses: infrequently - a decrease in the severity of hearing, noise in the ears; rarely -verthigo, reduced visual acuity, deafness.
From the side of the cardiovascular system: infrequent - a feeling of palpitations; rarely - lowering blood pressure; very rare - arrhythmia, including: ventricular tachycardia, increased interval Q-T, arrhythmia such as "pirouette."
From the digestive system: very often - nausea, diarrhea, abdominal pain, flatulence; often - vomiting; infrequently - gastritis, constipation, melena, anorexia; very rarely - a discoloration of the tongue, pseudomembranous colitis, pancreatitis.
From the liver and biliary tract: infrequently - hepatitis, hyperbilirubinemia, increased activity of "liver" transaminases; very rarely - cholestatic jaundice, liver failure (in rare cases with a fatal outcome, mainly on the background of a violation of liver function), fulminant hepatitis, liver necrosis.
Allergic reactions: often - itching, rash; infrequently - Stevens-Johnson syndrome, photosensitivity, urticaria; very rarely - anaphylactic reactions (including angioedema) in rare cases with fatal outcome, toxic epidermal necrolysis,erythema multiforme.
From the musculoskeletal system: often - arthralgia.
On the part of the genitourinary system: infrequently - increasing residual urea nitrogen and creatinine concentration in the blood plasma; very rarely - interstitial nephritis, acute renal failure.
Other: often - weakness; infrequently - pain in the chest, peripheral edema, asthenia, hyperglycemia, conjunctivitis.
Infections and invasions: infrequently - vaginitis, candidiasis of various localizations.
The occurrence of any side effect should be reported to the doctor in charge.