Classification of adverse reactions according to the frequency of development:
Frequently -> 1/100 and <1/10,
Infrequently -> 1/1000 and <1/100,
Rarely -> 1/10000 and <1/1000,
Very rarely - <1/10000.
From the blood and lymphatic systems:
Rarely - thrombocytopenia, neutropenia, eosinophilia, lymphopenia, hemolytic anemia, and leukopenia.
From the digestive system:
Often - diarrhea, nausea, vomiting, abdominal pain / spasms, dyspepsia. Infrequently - loose stools, flatulence, digestive disorders, anorexia. Rarely - constipation, discoloration of the tongue, pseudomembranous colitis, cholestatic jaundice, hepatitis, changes in laboratory parameters of liver function, hyperbilirubinemia, pancreatitis. Very rarely - liver dysfunction, liver necrosis (possibly fatal).
From the cardiovascular system:
Rarely - lowering blood pressure, increasing the interval Q-T, arrhythmia such as "pirouette", ventricular tachycardia, palpitation.
From the nervous system:
Infrequent - dizziness / vertigo, headache, drowsiness. Rarely - paresthesia, asthenia, insomnia, hyperactivity, aggressiveness, anxiety, nervousness.
From the sense organs:
Rarely, noise in the ears, reversible hearing impairment down to deafness (when taking high doses for a long time), a violation of the perception of taste and smell.
From the genitourinary system:
Rarely - increased residual urea nitrogen and creatinine concentration in blood plasma, interstitial nephritis, acute renal failure.
Allergic reactions:
Infrequent - itching, skin rashes. Rarely, angioedema, hives, photosensitivity, anaphylactic reaction, including edema (in rare cases, fatal), erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Other:
Infrequently - arthralgia. Rarely - weakness, peripheral edema, malaise, hyperglycemia.