Determination of the frequency of adverse reactions: often (> 1/100 and <1/10), sometimes (> 1/1000 and < 1/100), rarely (> 1/10 000 and <1/1000), very rarely (<1/10 000).
On the part of the hematopoiesis system: rarely - thrombocytopenia, neutropenia, eosinophilia, lymphopenia, leukopenia, hemolytic anemia.
From the central and the peripheral nervous system: sometimes - dizziness / vertigo, headache, drowsiness, convulsions; rarely - paresthesia, asthenia, insomnia, hyperactivity, aggressiveness, anxiety, nervousness, fainting, myasthenia gravis, weakness;
From the sense organs: rarely - noise in the ears; reversible hearing loss up to deafness (when taken in high doses for a long time), violation perception of taste and smell, impaired clarity of visual perception;
From the side of the cardiovascular system: rarely - malaise, chest pain, lower blood pressure, palpitations, arrhythmia, including ventricular tachycardia, increased interval QT, bidirectional ventricular tachycardia;
From the digestive system: often - nausea, vomiting, diarrhea, abdominal pain and cramps; sometimes - flatulence, digestive disorders, anorexia; rarely - constipation, discoloration of the tongue, gastritis, pancreatitis, pseudomembranous colitis, cholestatic jaundice, hepatitis, fulminant hepatitis, change of values of laboratory indicators of liver function; hyperbilirubinemia, hyperglycemia; rarely - violations of the liver and necrosis of the liver (possibly fatal).
Allergic reactions: sometimes itching, skin rashes; rarely - angioedema, urticaria, photosensitivity, anaphylactic reaction (in rare cases with a fatal outcome), erythema multiforme; syndrome Stevens-Johnson, toxic epidermal necrolysis.
From the musculoskeletal system: sometimes - arthralgia.
From the urinary system: rarely interstitial nephritis, acute renal failure, increased urea and creatinine concentrations in the blood plasma, peripheral edema.
Other: rarely - vaginitis, candidiasis, increased fatigue; conjunctivitis.