The incidence of side effects is classified according to the recommendations of the World Health Organization: very often - not less than 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01% (including isolated cases).
Infectious diseases: infrequently - candidiasis, including mucous membranes of the mouth and genitals, pneumonia, pharyngitis, gastroenteritis, respiratory diseases, rhinitis; very rarely - pseudomembranous colitis.
On the part of the blood and lymphatic system: often - eosinophilia, lymphopenia, basophilia, monocytosis, increasing the number of neutrophils; infrequently - leukopenia, neutropenia; very rarely - thrombocytopenia, hemolytic anemia.
From the side of metabolism and nutrition: often - anorexia.
Allergic reactions: often - itching, skin rash; infrequently - hypersensitivity reactions, photosensitization reaction, dermatitis, dry skin, sweating, urticaria, Stevens-Johnson syndrome, angioedema; very rarely - anaphylactic reaction, erythema multiforme, toxic epidermal necrolysis.
From the nervous system: often - headache, dizziness, paresthesia, a violation of taste sensations; infrequently - hypoesthesia, drowsiness, insomnia, nervousness, agitation; very rarely - anxiety, aggression, fainting, convulsions, psychomotor hyperactivity, loss of smell (or anosmia) and taste sensations, perversion of smell, myasthenia gravis, delirium, hallucinations.
From the side of the hearing organ and labyrinthine disorders: often - hearing disorder, deafness; infrequently, noise in the ears; rarely - vertigo.
From the side of the organ of vision: often - impaired vision.
From the side of the cardiovascular system: rarely - a feeling of palpitations, "tides" of blood to the face; very rarely - lowering blood pressure, increasing the interval QT on electrocardiogram, arrhythmia of the type "pirouette", ventricular tachycardia.
From the respiratory system: infrequently - shortness of breath, nosebleed.
From the gastrointestinal tract: very often - nausea, diarrhea, pain in abdomen, flatulence; often - indigestion, vomiting; infrequent - constipation, gastritis, dysphagia, bloating, dryness of the oral mucosa, belching, ulcers of the oral mucosa, increased secretion of the salivary glands; very rarely - a discoloration of the tongue, pancreatitis.
From the liver and bile ducts: infrequently - increased activity of "liver" transaminases, increased concentrations of bilirubin, hepatitis; rarely - a violation of the liver, cholestatic jaundice; very rarely - liver failure (in rare cases with a fatal outcome, mainly against a background of severe impairment of liver function); liver necrosis, fulminant hepatitis.
From the osteomuscular system and connective tissue: infrequently - osteoarthritis, myalgia, back pain, neck pain; very rarely - arthralgia.
From the side of the kidneys and urinary tract: infrequently - dysuria, pain in the kidney, an increase in the concentration of urea and creatinine in the blood plasma; very rarely - interstitial nephritis, acute renal failure.
From the genitals and mammary glands: infrequently - metrorrhagia, dysfunctions of testicles.
Laboratory indicators: often - a decrease in the concentration of bicarbonates in the blood plasma; infrequently, a change in the potassium concentration in the blood plasma, an increase in the activity of alkaline phosphatase, an increase in the concentration of chlorine and glucose in the blood plasma, an increase in the number of platelets, an increase in hematocrit, an increase in the concentration of bicarbonates and a change in the concentration of sodium in the blood plasma.
Other: infrequently - asthenia, malaise, fatigue, face swelling, chest pain, peripheral edema, fever.