The incidence of side effects listed below was determined according to the following (classification of the World Health Organization): very often (more than 10%), often (more than 1% and less than 10%), infrequently (more than 0.1% and less than 1%), rarely (more than 0.01% and less than 0.1%), very rarely (less than 0.01%), including individual messages, the frequency is unknown (can not be estimated using available data).
From the blood and lymphatic systems: often - eosinophilia, lymphocytopenia; infrequently - leukopenia, neutropenia; rarely - thrombocytopenia, hemolytic anemia.
From the nervous system: often - headache, dizziness, paresthesia; infrequently - hypoesthesia, drowsiness, insomnia; very rarely - fainting, convulsions, psychomotor hyperactivity, myasthenia gravis.
Disorders of the psyche: infrequently - nervousness; rarely - agitation; frequency is unknown - aggressiveness, anxiety, delirium, hallucinations.
From the sense organs: often - impaired vision, raceshearing, reversible hearing loss, including deafness (when taking high doses for a long time), vertigo, a violation of taste sensations; infrequently, noise in the ears; very rarely - loss of smell (or anosmia), perversion of smell, loss of taste sensations.
From the cardiovascular system: infrequently - a feeling of palpitations, "tides" of blood to the face; very rarely - lowering blood pressure, arrhythmia such as "pirouette", ventricular tachycardia, lengthening interval QT.
From the gastrointestinal tract: very often - nausea, flatulence, diarrhea; often - vomiting, abdominal pain / spasms, dyspepsia, gastroenteritis; infrequent - constipation, gastritis, dysphagia, dryness of the oral mucosa, belching, ulcers of the oral mucosa, increased secretion of the salivary glands; very rarely - a discoloration of the tongue, pancreatitis.
From the side of metabolism and nutrition: often - anorexia.
From the liver and bile ducts: infrequently - hepatitis; rarely - a violation of the liver, cholestatic jaundice; frequency unknown - hepatic insufficiency (in rare cases with a fatal outcome, mainly on the background of a violation of liver function), fulminant hepatitis, liver necrosis.
From the side of the kidneys and urinary tract: infrequently - an increase in the concentration of urea and creatinine in the blood plasma, dysuria, pain in the kidneys; very rarely - interstitial nephritis, acute renal failure.
From the genitals and the breast: infrequently - metrorrhagia, dysfunction of testicles.
From the immune system: infrequently - hypersensitivity reactions, angioedema; rarely - anaphylactic reactions (in rare cases, fatal).
From the skin and subcutaneous tissues: often - itching, skin rash; infrequently - Stevens-Johnson syndrome, photosensitivity, urticaria, dry skin, sweating, dermatitis; rarely - erythema multiforme, toxic epidermal necrolysis.
From the osteomuscular system and connective tissue: often - arthralgia; infrequently - osteoarthritis, myalgia, back pain, neck pain.
Infectious diseases: infrequently - candidiasis, including oral and genital mucosa, vaginal infections, fungal infections, bacterial infections; frequency unknown - pseudomembranous colitis.
From the respiratory system, chest and mediastinum: infrequently - pneumonia, pharyngitis, respiratory diseases, rhinitis, nosebleeds, dyspnea.
General disorders: infrequently - chest pain, peripheral edema, asthenia, fatigue, malaise, face swelling, fever.
Laboratory and instrumental data: often - an increase in the number of basophils, monocytes, neutrophils, a decrease or increase in the concentration of bicarbonates in the blood plasma; infrequent increase in the activity of "liver" transaminases, an increase in the concentration of bilirubin in the blood plasma, an increase in the activity of alkaline phosphatase, an increase in the level of chlorine in the blood plasma, an increase in the concentration of glucose in the blood plasma, an increase in the number of platelets, an increase in hematocrit, a change in the concentration of potassium and sodium in the blood plasma .