The frequency of side effects is classified according to the recommendations of the World Health Organization: very often - not less than 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely, not less than 0.01%. but less than 0.1%; very rarely - less than 0.01%: unknown frequency - can not be estimated from the available data.
Infectious diseases: infrequently - candidiasis. including mucous membranes of the oral cavity and genitals, pneumonia, pharyngitis, gastroenteritis, respiratory diseases, rhinitis: an unknown frequency is pseudomembranous colitis.
On the part of the blood and lymphatic system: infrequently - leukopenia, neutropenia, eosinophilia; very rarely - thrombocytopenia, hemolytic anemia.
From the side of metabolism and nutrition: infrequently - anorexia.
Allergic reactions: infrequently - angioedema, hypersensitivity reaction; an unknown frequency is an anaphylactic reaction.
From the nervous system: often - headache; infrequently - dizziness,a violation of taste sensations, paresthesia, drowsiness, insomnia, nervousness; rarely - agitation: unknown frequency - hypesthesia, anxiety, aggression, fainting, convulsions, psychomotor hyperactivity, loss of smell, perversion of smell, loss of taste sensations, myasthenia gravis, delirium, hallucinations.
From the side of the organs of sight: infrequently - impaired vision.
On the part of the hearing organs and labyrinthine disorders: infrequently, hearing disorder, vertigo; unknown frequency - hearing impairment, including deafness and / or tinnitus.
From the side of the cardiovascular system: infrequently - a feeling of palpitations, "tides" of blood to the face; unknown frequency - lowering of arterial pressure, increase in QT interval on electrocardiogram, arrhythmia of "pirouette" type, ventricular tachycardia.
From the respiratory system: infrequently - shortness of breath, nosebleed.
From the gastrointestinal tract: very often - diarrhea: often - nausea, vomiting, abdominal pain; infrequent - meteorism, dyspepsia, constipation, gastritis, dysphagia, bloating, dryness of the oral mucosa, belching, ulcers of the oral mucosa, increased secretion of the salivary glands; very rarely - a discoloration of the tongue, pancreatitis.
From the liver and biliary tract: infrequently - hepatitis; rarely - a violation of the liver, cholestatic jaundice; unknown frequency - hepatic insufficiency (in rare cases with a fatal outcome mainly on the background of severe violations of the liver function); liver necrosis, fulminant hepatitis.
From the skin and subcutaneous tissues: infrequently - skin rash, itching, hives, dermatitis, dry skin, sweating; rarely - the reaction of photosensitization; unknown frequency - Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme.
From the side of the musculoskeletal system: osteoarthritis, myalgia. pain in the back, pain in the neck; unknown frequency - arthralgia.
From the side of the kidneys and urinary tract: infrequently - dysuria, pain in the kidney; unknown frequency - interstitial nephritis, acute renal failure.
From the genitals and breast: infrequently - metrorrhagia. dysfunction of testicles.
Other: infrequently - asthenia, malaise, fatigue, face swelling, chest pain, fever, peripheral edema.
Laboratory data: often - a decrease in the number of lymphocytes, an increase in the number of eosinophils.increasing the number of basophils, increased the number of monocytes, increased neutrophil count, decreased bicarbonate concentration in the blood plasma, rarely - increase of aspartate aminotransferase activity, alanine aminotransferase, increased bilirubin concentration in blood plasma, increasing concentrations of urea in blood plasma, increasing the concentration of creatinine in the blood plasma, change the content potassium in the blood plasma, increased alkaline phosphatase activity in plasma, increasing chlorine content in the blood plasma, increased concen tration of blood glucose, increase the number of platelets, increasing hematocrit, increasing bicarbonate concentration in the blood plasma, a change in the sodium content in the blood plasma.