Frequency of side effects classified according to the recommendations of the World Health Organization: very often - not less than 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01%; The unknown frequency - ns can be estimated from the available data.
Infectious diseases: infrequently - candidiasis, including mucous membranes of the mouth and genitals, pneumonia, pharyngitis, gastroenteritis, respiratory diseases, rhinitis; an unknown frequency is pseudomembranous colitis.
From the side of the blood and lymphatic system: infrequently - leukopenia, neutropenia, eosinophilia; very rarely - thrombocytopenia, hemolytic anemia.
From the side of metabolism and nutrition: infrequently - anorexia.
Allergic reactions: infrequently angioedema, hypersensitivity reaction; an unknown frequency is an anaphylactic reaction.
From the nervous system: often - headache; infrequently - dizziness, a violation of taste, paresthesia, drowsiness, insomnia, nervousness; rarely - agitation: unknown frequency - hypodesis, anxiety, aggression, fainting, seizures, psychomotor hyperactivity, loss of smell, perversion of smell, loss of taste sensations, myasthenia gravis, delirium, hallucinations.
From the side of the organ of vision: infrequently - impaired vision.
From the side of the hearing organ and labyrinthine disorders: infrequently - hearing disorder, vertigo; unknown frequency - hearing impairment, including deafness and / or tinnitus.
From the cardiovascular system: infrequently - sensation palpitation, "tides" of blood to the face; unknown frequency - lowering of blood pressure. interval increase QT on the electrocardiogram, arrhythmia of the type "pirouette", ventricular tachycardia.
From the respiratory system: infrequently - shortness of breath, nosebleed.
From the gastrointestinal tract: very often diarrhea; often - nausea, vomiting, abdominal pain; infrequently - flatulence, indigestion, constipation, gastritis, dysphagia, bloating, dryness of the oral mucosa, eructation, ulcers of the mucosa oral cavity, increased secretion of salivary glands; very rarely - a discoloration of the tongue, pancreatitis.
From the liver and bile ducts: infrequently - hepatitis; rarely - a violation of the liver,cholestatic jaundice; unknown frequency - hepatic insufficiency (in rare cases with a fatal outcome mainly on the background of a severe liver function disorder); liver necrosis, fulminant hepatitis.
From the skin and subcutaneous tissues: infrequently - skin rash, itching. hives. dermatitis, dry skin, sweating; rarely - the reaction of photosensitization; unknown frequency - Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme.
From the musculoskeletal system: infrequently - osteoarthritis, myalgia, back pain, neck pain, unknown frequency - arthralgia.
From the side of the kidneys and urinary tract: infrequently - dysuria, pain in the kidney; unknown frequency interstitial nephritis, acute renal failure.
From the genitals and the breast: infrequently - metrorrhagia, dysfunction of testicles.
Other: infrequently - asthenia, malaise, fatigue, face swelling, chest pain, fever, peripheral edema.
Laboratory data: often a decrease in the number of lymphocytes, an increase in the number of eosinophils, an increase in the number of basophils, an increase in the number of monocytes,an increase in the number of neutrophils, a decrease in the concentration of bicarbonates in the blood plasma; infrequently - increased activity of aspartate aminotransferase, alanine aminotransferase, increased bilirubin concentration in blood plasma, increased urea concentration in blood plasma, increased creatinine concentration in blood plasma. a change in the content of potassium in the blood plasma, increased activity of alkaline phosphatase in the blood plasma, an increase in the level of chlorine in the blood plasma, increased blood glucose, increased platelet count, increased hematocrit, increased bicarbonate concentration in blood plasma, change in sodium in blood plasma.